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Substance Name: Bendamustine hydrochloride
RN: 3543-75-7
UNII: 981Y8SX18M
InChIKey: ZHSKUOZOLHMKEA-UHFFFAOYSA-N

Note

  • A nitrogen mustard compound that functions as an ALKYLATING ANTINEOPLASTIC AGENT and is used in the treatment of CHRONIC LYMPHOCYTIC LEUKEMIA and NON-HODGKIN'S LYMPHOMA.

Molecular Formula

  • C16-H21-Cl2-N3-O2.Cl-H

Molecular Weight

  • 394.7278
 

Classification Codes

  • Alkylating Agents
  • Antineoplastic Agents
  • Antineoplastic Agents, Alkylating
  • Drug / Therapeutic Agent
  • Noxae
  • Reproductive Effect
  • Treatment of Hematologic Cancer, Especially Non-Hodgkin's Lymphoma
  • Tumor Data

Names and Synonyms

Results Name

  • Bendamustine hydrochloride

Name of Substance

  • Bendamustine hydrochloride [USAN:JAN]

MeSH Heading

  • Bendamustine Hydrochloride

Synonyms

  • Bendamustin hydrochloride
  • Bendamustine HCl
  • Bendamustine hydrochloride
  • Bendamustine Hydrochloride Injection
  • Bendeka
  • Bendit
  • CCRIS 1864
  • Cytostasan
  • gamma(1-Methyl-5-bis(beta-chloraethyl)aminobenzimidazoyl-2)buttersaeurehydrochlorid
  • gamma(1-Methyl-5-bis(beta-chloraethyl)aminobenzimidazoyl-2)buttersaeurehydrochlorid [German]
  • IMET 3393
  • NSC 138783
  • Ribomustin
  • Ribomustine
  • SDX 105
  • SDX-105
  • SyB L-0501
  • Treanda
  • UNII-981Y8SX18M
  • ZIMET 33/93

Systematic Names

  • 1H-Benzimidazole-2-butanoic acid, 5-(bis(2-chloroethyl)amino)-1-methyl-, monohydrochloride (9CI)
  • 2-Benzimidazolebutyric acid, 5-(bis(2-chloroethyl)amino)-1-methyl-, monohydrochloride (8CI)
  • 2-Benzimidazolinebutryric acid, 1-methyl-5-bis(2-chloroethyl)amino-, hydrochloride
  • Cytostasan

Registry Numbers

CAS Registry Number

  • 3543-75-7

FDA UNII

  • 981Y8SX18M

Related Registry Number

  • 16506-27-7 (Parent)

System Generated Number

  • 0003543757

Molecular Formulas

Molecular Formula

  • C16-H21-Cl2-N3-O2.Cl-H

Molecular Formula Fragments

  • C16-H21-Cl2-N3-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C16H21Cl2N3O2.ClH/c1-20-14-6-5-12(21(9-7-17)10-8-18)11-13(14)19-15(20)3-2-4-16(22)23;/h5-6,11H,2-4,7-10H2,1H3,(H,22,23);1H

InChIKey

ZHSKUOZOLHMKEA-UHFFFAOYSA-N

Smiles

c12n(C)c(CCCC(=O)O)nc1cc(N(CCCl)CCCl)cc2.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 71mg/kg (71mg/kg)   Acta Biologica et Medica Germanica. Vol. 19, Pg. 543, 1967.
mouse LD50 intravenous 80mg/kg (80mg/kg) BLOOD: CHANGES IN SPLEEN Archives of Toxicology, Supplement. Vol. 8, Pg. 504, 1985.
mouse LD50 oral 250mg/kg (250mg/kg)   Archiv fuer Geschwulstforschung. Vol. 43, Pg. 16, 1974.
rat LD50 intravenous 40mg/kg (40mg/kg) BLOOD: CHANGES IN SPLEEN Archives of Toxicology, Supplement. Vol. 8, Pg. 504, 1985.
rat LD50 oral 200mg/kg (200mg/kg) BLOOD: CHANGES IN SPLEEN Archives of Toxicology, Supplement. Vol. 8, Pg. 504, 1985.