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Substance Name: Saxitoxin
RN: 35523-89-8
UNII: Q0638E899B
InChIKey: RPQXVSUAYFXFJA-HGRQIUPRSA-N

Notes

  • A compound that contains a reduced PURINE ring system but is not biosynthetically related to the purine alkaloids. It is a poison found in certain edible mollusks at certain times; elaborated by GONYAULAX and consumed by mollusks, fishes, etc. without ill effects. It is neurotoxic and causes RESPIRATORY PARALYSIS and other effects in MAMMALS, known as paralytic SHELLFISH poisoning.
  • Chemical Weapons Convention Schedule 1

Molecular Formula

  • C10-H17-N7-O4

Molecular Weight

  • 299.2893
 

Classification Codes

  • Natural Product
  • Noxae
  • Poisons
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Names and Synonyms

Name of Substance

  • Saxitoxin

MeSH Heading

  • Saxitoxin

Synonyms

  • Gonyaulax catenella poison
  • Mytilus californianus poison
  • Saxidomus giganteus poison
  • Saxitoxin
  • Saxitoxin hydrate
  • UNII-Q0638E899B

Systematic Names

  • 1H,10H-Pyrrolo(1,2-c)purine-10,10-diol, 2,6-diamino-4-(((amino-carbonyl)oxy)methyl)-3a,4,8,9-tetrahydro-, (3aS-(3a-alpha,4-alpha,10aR*))
  • 1H,10H-Pyrrolo(1,2-c)purine-10,10-diol, 2,6-diamino-4-(((aminocarbonyl)oxy)methyl)-3a,4,8,9-tetrahydro-, (3aS,4R,10aS)-
  • Saxitoxin (8CI)

Registry Numbers

CAS Registry Number

  • 35523-89-8

FDA UNII

  • Q0638E899B

Other Registry Numbers

  • 11017-04-2
  • 51938-46-6
  • 55803-44-6

System Generated Number

  • 0035523898

Structure Descriptors

InChI

1S/C10H17N7O4/c11-6-15-5-4(3-21-8(13)18)14-7(12)17-2-1-9(19,20)10(5,17)16-6/h4-5,19-20H,1-3H2,(H2,12,14)(H2,13,18)(H3,11,15,16)/t4-,5-,10-/m0/s1

InChIKey

RPQXVSUAYFXFJA-HGRQIUPRSA-N

Smiles

NC(=O)OC[C@@H]1N=C(N)N2CCC(O)(O)[C@@]23NC(=N[C@@H]13)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 oral 254ug/kg (0.254mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) Therapie. Vol. 24, Pg. 191, 1969.
chicken LD50 intravenous 3ug/kg (0.003mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 174, Pg. 393, 1968.
dog LD50 oral 181ug/kg (0.181mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) Therapie. Vol. 24, Pg. 191, 1969.
guinea pig LD50 oral 135ug/kg (0.135mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) Therapie. Vol. 24, Pg. 191, 1969.
guinea pig LDLo intravenous 10ug/kg (0.01mg/kg)   Toxicon. Vol. 28, Pg. 614, 1990.
monkey LD50 oral 364ug/kg (0.364mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) Therapie. Vol. 24, Pg. 191, 1969.
mouse LC50 inhalation 300ug/m3/24H (0.3mg/m3)   National Technical Information Service. Vol. AD-A203-563,
mouse LD50 intraperitoneal 8ug/kg (0.008mg/kg)   Toxicon. Vol. 7, Pg. 315, 1969.
mouse LD50 intravenous 8500ng/kg (0.0085mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 174, Pg. 393, 1968.
mouse LD50 oral 263ug/kg (0.263mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) Therapie. Vol. 24, Pg. 191, 1969.
mouse LD50 subcutaneous 12900ng/kg (0.0129mg/kg)   Toxicon. Vol. 23, Pg. 669, 1985.
pigeon LD50 oral 91ug/kg (0.091mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) Therapie. Vol. 24, Pg. 191, 1969.
rabbit LD50 intravenous 4ug/kg (0.004mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 174, Pg. 393, 1968.
rabbit LD50 oral 181ug/kg (0.181mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) Therapie. Vol. 24, Pg. 191, 1969.
rat LD50 intraperitoneal 10500ng/kg (0.0105mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) Therapie. Vol. 24, Pg. 191, 1969.
rat LD50 oral 192ug/kg (0.192mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) Therapie. Vol. 24, Pg. 191, 1969.