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Substance Name: Carindacillin [INN]
RN: 35531-88-5
UNII: 5V278481KE
InChIKey: JIRBAUWICKGBFE-MNRDOXJOSA-N

Note

  • Acid stable indanyl ester of carbenicillin for oral use; same side-effects as carbenicillin.

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents

Molecular Formula

  • C26-H26-N2-O6-S

Molecular Weight

  • 494.5654
 
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Names and Synonyms

Results Name

  • Carindacillin [INN]

Name of Substance

  • Carbenicillin indanyl
  • Carindacillin [INN]

Synonyms

  • BRN 1234450
  • Carbenicillin indanyl
  • Carindacilina
  • Carindacilina [INN-Spanish]
  • Carindacillin
  • Carindacilline
  • Carindacilline [INN-French]
  • Carindacillinum
  • Carindacillinum [INN-Latin]
  • CP 15464
  • Indanyl carbenicillin
  • N-((2R,5R,6R)-2-Carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)hept-6-yl)-2-phenylmalonamidsaeure
  • UNII-5V278481KE

Systematic Name

  • 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((3-((2,3-dihydro-1H-inden-5-yl)oxy)-1,3-dioxo-2-phenylpropyl)amino)-3,3-dimethyl-7-oxo-, (2S-(2-alpha,5-alpha,6-beta))-

Registry Numbers

CAS Registry Number

  • 35531-88-5

FDA UNII

  • 5V278481KE

System Generated Number

  • 0035531885

Structure Descriptors

InChI

1S/C26H26N2O6S/c1-26(2)20(24(31)32)28-22(30)19(23(28)35-26)27-21(29)18(15-7-4-3-5-8-15)25(33)34-17-12-11-14-9-6-10-16(14)13-17/h3-5,7-8,11-13,18-20,23H,6,9-10H2,1-2H3,(H,27,29)(H,31,32)/t18?,19-,20+,23-/m1/s1

InChIKey

JIRBAUWICKGBFE-MNRDOXJOSA-N

Smiles

CC1(C)S[C@@H]2[C@H](NC(=O)C(C(=O)Oc3ccc4CCCc4c3)c5ccccc5)C(=O)N2[C@H]1C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 500mg/kg (500mg/kg)   Chemotherapy Vol. 17, Pg. 334, 1972.
mouse LD50 oral 3600mg/kg (3600mg/kg)   Chemotherapy Vol. 17, Pg. 334, 1972.
rat LD50 oral 2gm/kg (2000mg/kg)   Chemotherapy Vol. 17, Pg. 334, 1972.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 3.77 (none)   EXP
Water Solubility 0.468 mg/L 25 EST
Vapor Pressure 2.56E-17 mm Hg 25 EST
Henry's Law Constant 7.30E-18 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 7.77E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.