Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Buflomedil hydrochloride
RN: 35543-24-9
UNII: 3J944AFS8S
InChIKey: ZDPACSAHMZADFZ-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Reproductive Effect

Molecular Formula

  • C17-H25-N-O4.Cl-H

Molecular Weight

  • 343.8484
 
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Buflomedil hydrochloride

Synonyms

  • 4-(1-Pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone hydrochloride
  • 4-(1-Pyrrolidyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone hydrochloride
  • A-48257
  • Bufedil
  • Buflan
  • Buflocit
  • Buflomedil HCl
  • Buflomedil hydrochloride
  • Chlorhydrate de (trimethoxy-2-4-6) phenyl-(pyrrolidine-3) propylacetone
  • Chlorhydrate de (trimethoxy-2-4-6) phenyl-(pyrrolidine-3) propylacetone [French]
  • EINECS 252-611-9
  • Fonzylane
  • Irrodan
  • Irrodan R
  • LL 1656
  • Lofton
  • Loftyl
  • Provas
  • UNII-3J944AFS8S

Systematic Names

  • 1-(3-(2,4,6-Trimethoxybenzoyl)propyl)pyrrolidinium chloride
  • 1-Butanone, 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-, hydrochloride

Registry Numbers

CAS Registry Number

  • 35543-24-9

FDA UNII

  • 3J944AFS8S

Related Registry Number

  • 55837-25-7 (Parent)

System Generated Number

  • 0035543249

Molecular Formulas

Molecular Formula

  • C17-H25-N-O4.Cl-H

Molecular Formula Fragments

  • C17-H25-N-O4
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C17H25NO4.ClH/c1-20-13-11-15(21-2)17(16(12-13)22-3)14(19)7-6-10-18-8-4-5-9-18;/h11-12H,4-10H2,1-3H3;1H

InChIKey

ZDPACSAHMZADFZ-UHFFFAOYSA-N

Smiles

c1(c(cc(cc1OC)OC)OC)C(=O)CCCN1CCCC1.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 50mg/kg (50mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

CARDIAC: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Therapie. Vol. 30, Pg. 207, 1975.
dog LDLo oral 80mg/kg (80mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 425, 1988.
mouse LD50 intramuscular 250mg/kg (250mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

KIDNEY, URETER, AND BLADDER: HEMATURIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Therapie. Vol. 30, Pg. 207, 1975.
mouse LD50 intravenous 40mg/kg (40mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 401, 1988.
mouse LD50 oral 275mg/kg (275mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

KIDNEY, URETER, AND BLADDER: HEMATURIA
Therapie. Vol. 30, Pg. 207, 1975.
mouse LD50 subcutaneous 286mg/kg (286mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 401, 1988.
rat LD50 intravenous 58500ug/kg (58.5mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 401, 1988.
rat LD50 oral 410mg/kg (410mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 401, 1988.
rat LD50 subcutaneous 796mg/kg (796mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 401, 1988.
women TDLo oral 55mg/kg (55mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: COMA

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Intensive Care Medicine. Vol. 20, Pg. 219, 1994.
women TDLo oral 60mg/kg (60mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: COMA
Intensive Care Medicine. Vol. 22, Pg. 57, 1996.
women TDLo oral 216mg/kg (216mg/kg) CARDIAC: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: COMA
Intensive Care Medicine. Vol. 22, Pg. 57, 1996.