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Substance Name: Viloxazine hydrochloride [USAN]
RN: 35604-67-2
UNII: OQW30I1332
InChIKey: HJOCKFVCMLCPTP-UHFFFAOYSA-N

Note

  • A morpholine derivative used as an antidepressant. It is similar in action to IMIPRAMINE.

Molecular Formula

  • C13-H19-N-O3.Cl-H

Molecular Weight

  • 273.758
 

Classification Codes

  • Antidepressant
  • Drug / Therapeutic Agent
  • Human Data
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Names and Synonyms

Name of Substance

  • Viloxazine hydrochloride
  • Viloxazine hydrochloride [USAN]

Synonyms

  • 2-((2-Ethoxyphenoxy)methyl)morpholine hydrochloride
  • 2-((o-Ethoxyphenoxy)methyl)morpholine hydrochloride
  • 2-(2-Ethoxyphenoxymethyl)-2,3,5,6-tetrahydro-1,4-oxazine hydrochloride
  • 2-(2-Ethoxyphenoxymethyl)tetrahydro-1,4-oxazine hydrochloride
  • CCRIS 1915
  • EINECS 252-638-6
  • ICI 58,834
  • Morpholine, 2-((2-ethoxyphenoxy)methyl)-, hydrochloride
  • UNII-OQW30I1332
  • Vicilan
  • Viloxacina clorhidrato
  • Viloxacina clorhidrato [Spanish]
  • Viloxazine HCl
  • Viloxazine hydrochloride
  • Vivalan

Systematic Names

  • 2-((2-Ethoxyphenoxy)methyl)morpholine hydrochloride
  • Emovit
  • Morpholine, 2-((2-ethoxyphenoxy)methyl)-, hydrochloride

Registry Numbers

CAS Registry Number

  • 35604-67-2

FDA UNII

  • OQW30I1332

Related Registry Number

  • 46817-91-8 (Parent)

System Generated Number

  • 0035604672

Molecular Formulas

Molecular Formula

  • C13-H19-N-O3.Cl-H

Molecular Formula Fragments

  • C13-H19-N-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C13H19NO3.ClH/c1-2-15-12-5-3-4-6-13(12)17-10-11-9-14-7-8-16-11;/h3-6,11,14H,2,7-10H2,1H3;1H

InChIKey

HJOCKFVCMLCPTP-UHFFFAOYSA-N

Smiles

c1(OC[C@@H]2OCCNC2)ccccc1OCC.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TDLo oral 25mg/kg/6D (25mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 British Medical Journal. Vol. 2, Pg. 96, 1977.
mouse LD50 intraperitoneal 162mg/kg (162mg/kg)   Farmaco, Edizione Scientifica. Vol. 35, Pg. 812, 1980.
mouse LD50 intravenous 60mg/kg (60mg/kg)   Journal of International Medical Research. Vol. 4, Pg. 83, 1976.
mouse LD50 oral 480mg/kg (480mg/kg)   Drug Development Research. Vol. 22, Pg. 385, 1991.
rat LD50 intraperitoneal 162mg/kg (162mg/kg)   Farmaco, Edizione Scientifica. Vol. 35, Pg. 812, 1980.
rat LD50 intravenous 60mg/kg (60mg/kg)   Journal of International Medical Research. Vol. 4, Pg. 83, 1976.
rat LD50 oral 2gm/kg (2000mg/kg)   Journal of International Medical Research. Vol. 4, Pg. 83, 1976.
women TDLo oral 30mg/kg (30mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: SLEEP		 Journal of International Medical Research. Vol. 4, Pg. 83, 1976.