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Substance Name: Darapladib [USAN:INN]
RN: 356057-34-6
UNII: UI1U1MYH09
InChIKey: WDPFJWLDPVQCAJ-UHFFFAOYSA-N

Note

  • A selective lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) inhibitor, on biomarkers of cardiovascular (CV) risk.

Molecular Formula

  • C36-H38-F4-N4-O2-S

Molecular Weight

  • 666.7802
 

Classification Codes

  • Enzyme Inhibitors
  • Phospholipase A2 Inhibitors
  • Treatment of Atherosclerosis
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Names and Synonyms

Name of Substance

  • Darapladib [USAN:INN]

Synonyms

  • 1H-Cyclopentapyrimidine-1-acetamide, N-(2-(diethylamino)ethyl)-2-(((4-fluorophenyl)methyl)thio)-4,5,6,7-tetrahydro-4-oxo-N-((4'-(trifluoromethyl)(1,1'-biphenyl)-4-yl)methyl)-
  • Darapladib
  • N-(2-(Diethylamino)ethyl)-2-(2-((4-fluorobenzyl)sulfanyl)-4-oxo-4,5,6,7-tetrahydro-1H-cyclopentapyrimidin-1-yl)-N-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)acetamide
  • SB 480848
  • SB-480848
  • SB480848
  • UNII-UI1U1MYH09

Registry Numbers

CAS Registry Number

  • 356057-34-6

FDA UNII

  • UI1U1MYH09

System Generated Number

  • 0356057346

Structure Descriptors

InChI

InChI=1S/C36H38F4N4O2S/c1-3-42(4-2)20-21-43(22-25-8-12-27(13-9-25)28-14-16-29(17-15-28)36(38,39)40)33(45)23-44-32-7-5-6-31(32)34(46)41-35(44)47-24-26-10-18-30(37)19-11-26/h8-19H,3-7,20-24H2,1-2H3

InChIKey

WDPFJWLDPVQCAJ-UHFFFAOYSA-N

Smiles

CCN(CC)CCN(Cc1ccc(cc1)c2ccc(cc2)C(F)(F)F)C(=O)CN3C4=C(CCC4)C(=O)N=C3SCc5ccc(F)cc5