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Substance Name: Benzbromarone [USAN:INN:BAN]
RN: 3562-84-3
UNII: 4POG0RL69O
InChIKey: WHQCHUCQKNIQEC-UHFFFAOYSA-N
Note
- Uricosuric that acts by increasing uric acid clearance. It is used in the treatment of gout.
Molecular Formula
- C17-H12-Br2-O3
Molecular Weight
- 424.0868
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Antirheumatic Agents
- Drug / Therapeutic Agent
- Gout Suppressants
- Renal Agents
- Reproductive Effect
- Uricosuric
- Uricosuric Agents
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Names and Synonyms
Name of Substance
- Benzbromarone
- Benzbromarone [USAN:INN:BAN]
MeSH Heading
- Benzbromarone
Synonyms
- (2-Ethyl-3-benzofuranyl)-(3,5-dibrom-4-hydroxyphenyl)keton
- 2-Ethyl-3-(3,5-dibrom-4-hydroxybenzoyl)benzofuran
- 3,5-Dibromo-4-hydroxyphenyl-2-ethyl-3-benzofuranyl ketone
- 5-18-02-00335 (Beilstein Handbook Reference)
- Azubromaron
- Benzbromaron
- Benzbromarone
- Benzbromaronum
- Benzbromaronum [INN-Latin]
- Benzobromarona
- Benzobromarona [INN-Spanish]
- Benzofuran, 3-(3,5-dibromo-4-hydroxybenzoyl)-2-ethyl-
- BRN 0273668
- Desuric
- EINECS 222-630-7
- Exurate
- Harolan
- Hipurik
- L 2214
- L 2214-Labaz
- L-2214
- L2214
- L2214-Labaz
- Minuric
- MJ 10061
- Narcaricin
- Normurat
- NSC 85433
- UNII-4POG0RL69O
- Uricovac
- Urinorm
Systematic Names
- Benzbromarone
- Ketone, 3,5-dibromo-4-hydroxyphenyl 2-ethyl-3-benzofuranyl
- Methanone, (3,5-dibromo-4-hydroxyphenyl)(2-ethyl-3-benzofuranyl)-
Registry Numbers
CAS Registry Number
- 3562-84-3
FDA UNII
- 4POG0RL69O
System Generated Number
- 0003562843
Structure Descriptors
InChI
InChI=1S/C17H12Br2O3/c1-2-13-15(10-5-3-4-6-14(10)22-13)16(20)9-7-11(18)17(21)12(19)8-9/h3-8,21H,2H2,1H3InChIKey
WHQCHUCQKNIQEC-UHFFFAOYSA-NSmiles
CCc1oc2ccccc2c1C(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 146mg/kg (146mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED | Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 341, 1972. |
mouse | LD50 | intravenous | 77mg/kg (77mg/kg) | KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) | Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 341, 1972. |
mouse | LD50 | oral | 618mg/kg (618mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 232, 1979. | |
mouse | LD50 | subcutaneous | 4120mg/kg (4120mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 232, 1979. | |
rat | LD50 | intraperitoneal | 239mg/kg (239mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 232, 1979. | |
rat | LD50 | oral | 248mg/kg (248mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 232, 1979. | |
rat | LD50 | subcutaneous | 1230mg/kg (1230mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 232, 1979. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 151 | deg C | EXP | |
log P (octanol-water) | 6.030 | (none) | EST | |
Atmospheric OH Rate Constant | 4.17E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.