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Substance Name: Aprofene [INN]
RN: 3563-01-7
UNII: PL791XXJ7B
InChIKey: DIDYGLSKVUKRRP-UHFFFAOYSA-N

Classification Codes

  • Autonomic Agents
  • Drug / Therapeutic Agent
  • Parasympatholytics
  • Peripheral Nervous System Agents

Molecular Formula

  • C21-H27-N-O2

Molecular Weight

  • 325.449
 
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Names and Synonyms

Name of Substance

  • Aprofen
  • Aprofene
  • Aprofene [INN]

Synonyms

  • 2,2-Diphenylpropionic acid 2-diethylaminoethyl ester
  • 2-Diethylaminoethyl 2,2-diphenylpropionate
  • 4-09-00-02535 (Beilstein Handbook Reference)
  • alpha,alpha-Diphenylpropionic acid 2-diethylaminoethyl ester
  • alpha,alpha-Diphenylpropionic acid beta-diethylaminoethyl ester
  • alpha-Methyl-alpha-phenylbenzeneacetic acid 2-(diethylamino)ethyl ester
  • Aprofen
  • Aprofene
  • Aprofeno
  • Aprofeno [INN-Spanish]
  • Aprofenum
  • Aprofenum [INN-Latin]
  • Aprophen
  • Aprophenum
  • BRN 2509326
  • UNII-PL791XXJ7B

Systematic Names

  • 2-Diethylaminoethyl 2,2-diphenylpropionate
  • Benzeneacetic acid, alpha-methyl-alpha-phenyl-, 2-(diethylamino)ethyl ester (9CI)
  • Propionic acid, 2,2-diphenyl-, 2-(diethylamino)ethyl ester

Registry Numbers

CAS Registry Number

  • 3563-01-7

FDA UNII

  • PL791XXJ7B

Related Registry Number

  • 2589-00-6 (hydrochloride)

System Generated Number

  • 0003563017

Structure Descriptors

InChI

1S/C21H27NO2/c1-4-22(5-2)16-17-24-20(23)21(3,18-12-8-6-9-13-18)19-14-10-7-11-15-19/h6-15H,4-5,16-17H2,1-3H3

InChIKey

DIDYGLSKVUKRRP-UHFFFAOYSA-N

Smiles

N(CCOC(C(c1ccccc1)(c1ccccc1)C)=O)(CC)CC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 125mg/kg (125mg/kg)   Pharmaceutical Chemistry Journal Vol. 4, Pg. 7, 1970.
mouse LD50 subcutaneous 370mg/kg (370mg/kg)   Russian Pharmacology and Toxicology Vol. 31, Pg. 53, 1968.