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Substance Name: Glysobuzole [INN:BAN:DCF]
RN: 3567-08-6
UNII: 887VHL8899
InChIKey: LZCBNYVJTNCPDR-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Tumor Data

Molecular Formula

  • C13-H17-N3-O3-S2

Molecular Weight

  • 327.4273
 
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Names and Synonyms

Name of Substance

  • Glysobuzole
  • Glysobuzole [INN:BAN:DCF]

Synonyms

  • 1,3,4-Thiadiazole, 5-isobutyl-2-(p-methoxybenzenesulfonamido)-
  • 2-(p-Anisylsulfonamido)-5-isobutyl-1,3,4-thiadiazole
  • 2-(p-Methoxybenzenesulfonamido)-5-isobutyl-1,3,4-thiadiazole
  • 4-27-00-08084 (Beilstein Handbook Reference)
  • 5-Isobutyl-2-p-methoxybenzenesulfonamido-1,3,4-thiadiazole
  • 8002 C. B.
  • 8002 CB
  • BRN 0295174
  • FWH 114
  • Glisobuzol
  • Glisobuzol [INN-Spanish]
  • Glysobuzol
  • Glysobuzole
  • Glysobuzolum
  • Glysobuzolum [INN-Latin]
  • Isobuzol
  • Isobuzole
  • N-(5-Isobutyl-1,3,4-thiadiazol-2-yl)-p-methoxybenzenesulfonamide
  • NSC 34014
  • Stabinol
  • UNII-887VHL8899

Systematic Names

  • Benzenesulfonamide, 4-methoxy-N-(5-(2-methylpropyl)-1,3,4-thiadiazol-2-yl)- (9CI)
  • Benzenesulfonamide, N-(5-isobutyl-1,3,4-thiadiazol-2-yl)-p-methoxy-
  • N-(5-Isobutyl-1,3,4-thiadiazol-2-yl)-p-methoxybenzenesulfonamide

Registry Numbers

CAS Registry Number

  • 3567-08-6

FDA UNII

  • 887VHL8899

System Generated Number

  • 0003567086

Structure Descriptors

InChI

1S/C13H17N3O3S2/c1-9(2)8-12-14-15-13(20-12)16-21(17,18)11-6-4-10(19-3)5-7-11/h4-7,9H,8H2,1-3H3,(H,15,16)

InChIKey

LZCBNYVJTNCPDR-UHFFFAOYSA-N

Smiles

CC(C)Cc1nnc(s1)NS(=O)(=O)c2ccc(cc2)OC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD oral > 1gm/kg (1000mg/kg) BEHAVIORAL: TREMOR

GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: MUSCLE WEAKNESS
Toxicology and Applied Pharmacology. Vol. 8, Pg. 13, 1966.
mouse LD50 intraperitoneal 250mg/kg (250mg/kg)   Toxicology and Applied Pharmacology. Vol. 4, Pg. 631, 1962.
mouse LD50 intraperitoneal 250mg/kg (250mg/kg) BEHAVIORAL: ATAXIA

ENDOCRINE: HYPOGLYCEMIA
Toxicology and Applied Pharmacology. Vol. 4, Pg. 631, 1962.
mouse LD50 oral 468mg/kg (468mg/kg)   Toxicology and Applied Pharmacology. Vol. 8, Pg. 13, 1966.
rat LD50 oral 534mg/kg (534mg/kg)   Toxicology and Applied Pharmacology. Vol. 8, Pg. 13, 1966.