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Substance Name: Dextromoramide [INN:BAN]
RN: 357-56-2
UNII: 9S4S6CIY83
InChIKey: INUNXTSAACVKJS-OAQYLSRUSA-N
Note
- An opioid analgesic structurally related to METHADONE and used in the treatment of severe pain. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1070)
Molecular Formula
- C25-H32-N2-O2
Molecular Weight
- 392.5398
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- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Analgesics
- Analgesics, Opioid
- Central Nervous System Agents
- Central Nervous System Depressants
- Drug / Therapeutic Agent
- Human Data
- Narcotics
- Peripheral Nervous System Agents
- Sensory System Agents
Superlist Classification Code
- DEA Schedule I
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Links to Resources
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Regulatory Agencies (Superlist Locators)
Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- Dextromoramide
- Dextromoramide [INN:BAN]
MeSH Heading
- Dextromoramide
Synonyms
- (+)-2,2-Diphenyl-3-methyl-4-morpholinobutyrylpyrrolidine
- (+)-3-Methyl-4-morpholino-2,2-diphenyl-1-(pyrrolidin-1-yl)butanon
- (+)-N-(3-Methyl-4-morpholino-2,2-diphenylbutyryl)pyrrolidin
- Alcoid
- Dauran
- Destromoramide
- Destromoramide [DCIT]
- Dextromoramida
- Dextromoramida [INN-Spanish]
- Dextromoramide
- Dextromoramidum
- Dextromoramidum [INN-Latin]
- Dimorlin
- EINECS 206-613-1
- Jetrium
- Jetrium R
- Linfadol
- MCP 875
- Moramide
- Narcolo
- Palfadonna
- Pyrrolamidol
- Pyrrolamidolum
- R 875
- SKF 5137
- Troxilan
- UNII-9S4S6CIY83
- Yetrium
Systematic Names
- Dextromoramide
- Pyrrolidine, 1-(2,2-diphenyl-3-methyl-4-morpholinobutyryl)-, (+)-
- Pyrrolidine, 1-(3-methyl-4-(4-morpholinyl)-1-oxo-2,2-diphenylbutyl)-, (S)-
Superlist Names
- DEA No. 9613
- Dextromoramide
- Narcolo
- Palfium
Registry Numbers
CAS Registry Number
- 357-56-2
FDA UNII
- 9S4S6CIY83
System Generated Number
- 0000357562
Structure Descriptors
InChI
InChI=1S/C25H32N2O2/c1-21(20-26-16-18-29-19-17-26)25(22-10-4-2-5-11-22,23-12-6-3-7-13-23)24(28)27-14-8-9-15-27/h2-7,10-13,21H,8-9,14-20H2,1H3/t21-/m1/s1InChIKey
INUNXTSAACVKJS-OAQYLSRUSA-NSmiles
C[C@H](CN1CCOCC1)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
human | TDLo | intramuscular | 57ug/kg (0.057mg/kg) | BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | New York State Journal of Medicine. Vol. 61, Pg. 83, 1961. |
mouse | LD50 | intravenous | 21mg/kg (21mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Journal of Pharmacy and Pharmacology. Vol. 9, Pg. 730, 1957. |
mouse | LD50 | oral | 168mg/kg (168mg/kg) | LUNGS, THORAX, OR RESPIRATION: CYANOSIS GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Journal of Pharmacy and Pharmacology. Vol. 9, Pg. 730, 1957. |
mouse | LD50 | subcutaneous | 140mg/kg (140mg/kg) | British Journal of Pharmacology and Chemotherapy. Vol. 17, Pg. 433, 1961. | |
rat | LD50 | intravenous | 13mg/kg (13mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Journal of Pharmacy and Pharmacology. Vol. 9, Pg. 730, 1957. |
rat | LD50 | oral | 71800ug/kg (71.8mg/kg) | Drug Development Research. Vol. 1, Pg. 1, 1981. | |
rat | LD50 | subcutaneous | 50mg/kg (50mg/kg) | LUNGS, THORAX, OR RESPIRATION: CYANOSIS GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Journal of Pharmacy and Pharmacology. Vol. 9, Pg. 730, 1957. |
women | TDLo | intramuscular | 200ug/kg (0.2mg/kg) | LUNGS, THORAX, OR RESPIRATION: CYANOSIS GASTROINTESTINAL: NAUSEA OR VOMITING | Practitioner. Vol. 197, Pg. 348, 1966. |
women | TDLo | subcutaneous | 150ug/kg (0.15mg/kg) | BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | British Medical Journal. Vol. 1, Pg. 211, 1959. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 182 | deg C | EXP | |
log P (octanol-water) | 3.61 | (none) | EXP | |
Water Solubility | 2.810 | mg/L | 25 | EST |
Vapor Pressure | 2.43E-10 | mm Hg | 25 | EST |
Henry's Law Constant | 2.17E-15 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 1.92E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.