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Substance Name: Nifurthiazole [USAN:INN]
RN: 3570-75-0
UNII: 76C4HVE5L9
InChIKey: DUWYZHLZDVCZIO-UHFFFAOYSA-N

Molecular Formula

  • C8-H6-N4-O4-S

Molecular Weight

  • 254.2254
 

Classification Codes

Classification Codes

  • Antibacterial
  • Mutation Data
  • Tumor Data

Superlist Classification Code

  • Overall Carcinogenic Evaluation: Group 2B
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Names and Synonyms

Name of Substance

  • Nefurthiazole
  • Nifurthiazole
  • Nifurthiazole [USAN:INN]

Synonyms

  • 2-(2-Formylhydrazino)-4-(5-nitro-2-furyl)thiazole
  • AS-17665
  • BRN 0551526
  • CCRIS 433
  • FNT
  • Formic 2-(4-(5-nitrofuryl)-2-thiazolyl)hydrazide
  • Formic acid 2-(4-(5-nitro-2-furyl)-2-thiazolyl)hydrazide
  • HSDB 2943
  • Hydrazinecarboxaldehyde, 2-(4-(5-nitro-2-furanyl)-2-thiazolyl)-
  • Nifurthiazol
  • Nifurthiazole
  • Nifurthiazolum
  • Nifurthiazolum [INN-Latin]
  • Nifurtiazol
  • Nifurtiazol [INN-Spanish]
  • NSC-525334
  • UNII-76C4HVE5L9

Systematic Names

  • Formic acid, 2-(4-(5-nitro-2-furyl)-2-thiazolyl)hydrazide
  • Hydrazinecarboxaldehyde, 2-(4-(5-nitro-2-furanyl)-2-thiazolyl)-
  • Nifurthiazole

Superlist Name

  • 2-(2-Formylhydrazino)-4-(5-nitro-2-furyl)thiazole

Registry Numbers

CAS Registry Number

  • 3570-75-0

FDA UNII

  • 76C4HVE5L9

System Generated Number

  • 0003570750

Structure Descriptors

InChI

1S/C8H6N4O4S/c13-4-9-11-8-10-5(3-17-8)6-1-2-7(16-6)12(14)15/h1-4H,(H,9,13)(H,10,11)

InChIKey

DUWYZHLZDVCZIO-UHFFFAOYSA-N

Smiles

c1cc(oc1c2csc(n2)NNC=O)[N+](=O)[O-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 445mg/kg (445mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Antimicrobial Agents and Chemotherapy Vol. -, Pg. 268, 1962.
mouse LD50 oral 1400mg/kg (1400mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Antimicrobial Agents and Chemotherapy Vol. -, Pg. 268, 1962.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 215.5 dec deg C   EXP
log P (octanol-water) 0.990 (none)   EST
Water Solubility 124 mg/L 25 EST
Vapor Pressure 2.31E-09 mm Hg 25 EST
Henry's Law Constant 7.59E-18 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.72E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.