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Substance Name: Tolmetin sodium
RN: 35711-34-3
UNII: WL259637KX
InChIKey: QGUALMNFRILWRA-UHFFFAOYSA-M

Note

  • A non-steroidal anti-inflammatory agent (ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL) similar in mode of action to INDOMETHACIN.

Molecular Formulas

  • C14-H12-N-O3.Na
  • C15-H15-N-O3.Na

Molecular Weight

  • 279.27
 

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Reproductive Effect
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Names and Synonyms

Results Name

  • Tolmetin sodium

Name of Substance

  • Tolmetin sodium anhydrous

Synonyms

  • 1-Methyl-5-(p-toluoyl)-2-pyrroleacetic acid
  • 1H-Pyrrole-2-acetic acid, 1-methyl-5-(4-methylbenzoyl)-, sodium salt
  • EINECS 252-687-3
  • Sodium tolmetin
  • Toleclin
  • Tolectin
  • Tolectin 600
  • Tolectin DS
  • Tolmetin sodium
  • UNII-WL259637KX

Systematic Names

  • 1H-Pyrrole-2-acetic acid, 1-methyl-5-(p-toluoyl)-, sodium salt
  • Sodium 1-methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetate

Registry Numbers

CAS Registry Number

  • 35711-34-3

FDA UNII

  • WL259637KX

Related Registry Number

  • 26171-23-3 (Parent)

System Generated Number

  • 0035711343

Molecular Formulas

Molecular Formulas

  • C14-H12-N-O3.Na
  • C15-H15-N-O3.Na

Molecular Formula Fragments

  • C14-H12-N-O3
  • C15-H15-N-O3
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C15H15NO3.Na/c1-10-3-5-11(6-4-10)15(19)13-8-7-12(16(13)2)9-14(17)18;/h3-8H,9H2,1-2H3,(H,17,18);/q;+1/p-1

InChIKey

QGUALMNFRILWRA-UHFFFAOYSA-M

Smiles

c1(n(C)c(CC(=O)[O-])cc1)C(c1ccc(C)cc1)=O.[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 2520mg/kg/8W- (2520mg/kg) BLOOD: THROMBOCYTOPENIA Arthritis and Rheumatism. Vol. 25, Pg. 1144, 1982.
dog LD50 oral > 800mg/kg (800mg/kg)   Pharmacological and Biochemical Properties of Drug Substances. Vol. 1, Pg. 233, 1977.
hamster LD50 oral 1584mg/kg (1584mg/kg)   Pharmacological and Biochemical Properties of Drug Substances. Vol. 1, Pg. 233, 1977.
human TDLo oral 8mg/kg (8mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

VASCULAR: SHOCK
JAMA, Journal of the American Medical Association. Vol. 240, Pg. 246, 1978.
man TDLo oral 538mg/kg/61D- (538mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE" JAMA, Journal of the American Medical Association. Vol. 243, Pg. 1263, 1980.
mouse LD50 intraperitoneal 690mg/kg (690mg/kg)   Drugs in Japan Vol. 6, Pg. 532, 1982.
mouse LD50 intravenous > 622mg/kg (622mg/kg)   Drugs in Japan Vol. 6, Pg. 532, 1982.
mouse LD50 oral 899mg/kg (899mg/kg)   Pharmacological and Biochemical Properties of Drug Substances. Vol. 1, Pg. 233, 1977.
mouse LD50 subcutaneous 670mg/kg (670mg/kg)   Drugs in Japan Vol. 6, Pg. 532, 1982.
rat LD50 intraperitoneal 770mg/kg (770mg/kg)   Drugs in Japan Vol. 6, Pg. 532, 1982.
rat LD50 intravenous > 724mg/kg (724mg/kg)   Drugs in Japan Vol. 6, Pg. 532, 1982.
rat LD50 oral 914mg/kg (914mg/kg)   Pharmacological and Biochemical Properties of Drug Substances. Vol. 1, Pg. 233, 1977.
rat LD50 subcutaneous 1050mg/kg (1050mg/kg)   Drugs in Japan Vol. 6, Pg. 532, 1982.
women TDLo oral 8mg/kg (8mg/kg) LIVER: LIVER FUNCTION TESTS IMPAIRED

SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE

SPINAL CORD: MENINGEAL CHANGES
JAMA, Journal of the American Medical Association. Vol. 245, Pg. 67, 1981.