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Substance Name: Cyclazocine [USAN:INN]
RN: 3572-80-3
UNII: J5W1B1159C
InChIKey: YQYVFVRQLZMJKJ-UHFFFAOYSA-N

Note

  • An analgesic with mixed narcotic agonist-antagonist properties.

Molecular Formula

  • C18-H25-N-O

Molecular Weight

  • 271.4015
 

Classification Codes

  • Analgesic
  • Analgesics
  • Analgesics, Non-Narcotic
  • Central Nervous System Agents
  • Drug / Therapeutic Agent
  • Narcotic Antagonists
  • Peripheral Nervous System Agents
  • Reproductive Effect
  • Sensory System Agents
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Names and Synonyms

Name of Substance

  • Cyclazocine
  • Cyclazocine [USAN:INN]

MeSH Heading

  • Cyclazocine

Synonyms

  • 2,6-Methano-3-benzazocin-8-ol, 3-(cyclopropylmethyl)-1,2,3,4,5,6-hexahydro-6,11-dimethyl-
  • 2-Cyclopropylmethyl-2'-hydroxy-5,9-dimethyl-6,7-benzomorphan
  • 2-Cyclopropylmethyl-5,9-dimethyl-2'-hydroxy-6,7-benzomorphan
  • 3-(Cyclopropylmethyl)-1,2,3,4,5,6-hexahydro-6,11-dimethyl-2,6-methano-3-benzazocin-8-ol
  • 3-Cyclopropylmethyl-6(eq),11(ax)-dimethyl-2,6-methano-3-benzazocin-8-ol
  • Ciclazocina
  • Ciclazocina [INN-Spanish]
  • Cyclazocine
  • Cyclazocinum
  • Cyclazocinum [INN-Latin]
  • EINECS 222-689-9
  • NIH 7981
  • NSC 107429
  • NSC-107429
  • UM 407
  • UNII-J5W1B1159C
  • Win 20,740
  • WIN 20740

Systematic Names

  • 2,6-Methano-3-benzazocin-8-ol, 1,2,3,4,5,6-hexahydro-3-(cyclopropylmethyl)-6,11-dimethyl-
  • 2,6-Methano-3-benzazocin-8-ol, 3-(cyclopropylmethyl)-1,2,3,4,5,6-hexahydro-6,11-dimethyl-
  • Cyclazocine

Registry Numbers

CAS Registry Number

  • 3572-80-3

FDA UNII

  • J5W1B1159C

System Generated Number

  • 0003572803

Structure Descriptors

InChI

1S/C18H25NO/c1-12-17-9-14-5-6-15(20)10-16(14)18(12,2)7-8-19(17)11-13-3-4-13/h5-6,10,12-13,17,20H,3-4,7-9,11H2,1-2H3

InChIKey

YQYVFVRQLZMJKJ-UHFFFAOYSA-N

Smiles

c12[C@@]3([C@@H]([C@@H]([N@@](CC4CC4)CC3)Cc1ccc(c2)O)C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 28mg/kg (28mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 165, Pg. 112, 1967.
mouse LD50 subcutaneous 150mg/kg (150mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 2009, 1976.
mouse LDLo intraperitoneal 10mg/kg (10mg/kg)   Research Communications in Chemical Pathology and Pharmacology. Vol. 17, Pg. 255, 1977.
rat LD50 intravenous 32mg/kg (32mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 165, Pg. 112, 1967.
rat LD50 subcutaneous 310mg/kg (310mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 143, Pg. 141, 1964.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 202.5 deg C   EXP
log P (octanol-water) 4.510 (none)   EST
Atmospheric OH Rate Constant 1.50E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.