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Substance Name: Thermozymocidin
RN: 35891-70-4
UNII: YRM4E8R9ST
InChIKey: ZZIKIHCNFWXKDY-GNTQXERDSA-N

Note

  • A serine palmitoyltransferase inhibitor; FTY720 is an analog.

Molecular Formula

  • C21-H39-N-O6

Molecular Weight

  • 401.54
 

Classification Codes

  • Anti-Infective Agents
  • Antifungal Agents
  • Drug / Therapeutic Agent
  • Immunologic Factors
  • Immunosuppressive Agents
  • Natural Product
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Names and Synonyms

Name of Substance

  • Thermozymocidin

Synonyms

  • Myriocin
  • Thermozymocidin
  • UNII-YRM4E8R9ST

Systematic Name

  • 6-Eicosenoic acid, 2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-, (2S-(2R*,3S*,4S*,6E))-

Registry Numbers

CAS Registry Number

  • 35891-70-4

FDA UNII

  • YRM4E8R9ST

Other Registry Numbers

  • 36564-60-0
  • 37836-36-5

System Generated Number

  • 0035891704

Structure Descriptors

InChI

1S/C21H39NO6/c1-2-3-4-10-13-17(24)14-11-8-6-5-7-9-12-15-18(25)19(26)21(22,16-23)20(27)28/h9,12,18-19,23,25-26H,2-8,10-11,13-16,22H2,1H3,(H,27,28)/b12-9+/t18-,19+,21+/m1/s1

InChIKey

ZZIKIHCNFWXKDY-GNTQXERDSA-N

Smiles

C([C@]([C@H]([C@H](O)C\C=C\CCCCCCC(=O)CCCCCC)O)(N)CO)(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo subcutaneous 250ug/kg (0.25mg/kg)   "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 3, Pg. 2067, 1978.
mouse LD50 intraperitoneal 5mg/kg (5mg/kg)   Journal of Antibiotics. Vol. 25, Pg. 109, 1972.
mouse LD50 oral 300mg/kg (300mg/kg)   Journal of Antibiotics. Vol. 25, Pg. 109, 1972.
rat LD50 intraperitoneal 2mg/kg (2mg/kg)   Journal of Antibiotics. Vol. 25, Pg. 109, 1972.