Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Tiaramide hydrochloride [USAN:JAN]
RN: 35941-71-0
UNII: ITY1616X9T
InChIKey: UKNGDQSYPNBJAO-UHFFFAOYSA-N

Classification Codes

  • Anti-Asthmatic
  • Drug / Therapeutic Agent
  • Reproductive Effect
  • Skin / Eye Irritant

Molecular Formula

  • C15-H18-Cl-N3-O3-S.Cl-H

Molecular Weight

  • 392.3051
 
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Tiaramide hydrochloride
  • Tiaramide hydrochloride [USAN:JAN]

Synonyms

  • 2-Benzothiazolinone, 5-chloro-3-(4-(2-hydroxyethyl)-1-piperazinyl)carbonylmethyl-, HCl
  • 4-((5-Chloro-2-oxo-3(2H)-benzothiazolyl)acetyl)-1-piperazineethanol hydrochloride
  • 4-((5-Chloro-2-oxo-3-benzothiazolinyl)acetyl)-1-piperazineethanol monohydrochloride
  • 5-Chloro-3-(4-(2-hydroxyethyl)-1-piperazinyl)carbonylmethyl-2-benzothiazolinone hydrochloride
  • EINECS 252-802-7
  • FK 1160
  • NSC 289337
  • NTA 194
  • NTA-194
  • Solantal
  • Thiaramide
  • Thiaramide [German]
  • Tiaramide HCl
  • Tiaramide hydrochloride
  • Tiaramide hydrochloride-r
  • UNII-ITY1616X9T
  • USV 2592 HCl
  • Ventaval tabletten

Systematic Names

  • 1-Piperazineethanol, 4-((5-chloro-2-oxo-3(2H)-benzothiazolyl)acetyl)-, hydrochloride
  • 1-Piperazineethanol, 4-((5-chloro-2-oxo-3(2H)-benzothiazolyl)acetyl)-, monohydrochloride
  • 4-((5-Chloro-2-oxo-2H-benzothiazol-3-yl)acetyl)piperazine-1-ethanol monohydrochloride

Registry Numbers

CAS Registry Number

  • 35941-71-0

FDA UNII

  • ITY1616X9T

Related Registry Number

  • 32527-55-2 (Parent)

System Generated Number

  • 0035941710

Molecular Formulas

Molecular Formula

  • C15-H18-Cl-N3-O3-S.Cl-H

Molecular Formula Fragments

  • C15-H18-Cl-N3-O3-S
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C15H18ClN3O3S.ClH/c16-11-1-2-13-12(9-11)19(15(22)23-13)10-14(21)18-5-3-17(4-6-18)7-8-20;/h1-2,9,20H,3-8,10H2;1H

InChIKey

UKNGDQSYPNBJAO-UHFFFAOYSA-N

Smiles

c1cc2c(cc1Cl)n(c(=O)s2)CC(=O)N3CCN(CC3)CCO.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 157mg/kg (157mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 504, 1973.
dog LD50 oral > 4gm/kg (4000mg/kg)   Drugs in Japan Vol. 6, Pg. 451, 1982.
mouse LD50 intraperitoneal 298mg/kg (298mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 504, 1973.
mouse LD50 intravenous 178mg/kg (178mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 504, 1973.
mouse LD50 oral 564mg/kg (564mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 504, 1973.
mouse LD50 subcutaneous 375mg/kg (375mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 504, 1973.
rabbit LD50 intravenous 171mg/kg (171mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 504, 1973.
rabbit LD50 oral 1850mg/kg (1850mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 504, 1973.
rat LD50 intraperitoneal 530mg/kg (530mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 504, 1973.
rat LD50 intravenous 203mg/kg (203mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 504, 1973.
rat LD50 oral 2300mg/kg (2300mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 225, 1982.
rat LD50 subcutaneous 930mg/kg (930mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 504, 1973.