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Substance Name: Piribedil [INN:DCF]
RN: 3605-01-4
UNII: DO22K1PRDJ
InChIKey: OQDPVLVUJFGPGQ-UHFFFAOYSA-N

Note

  • A dopamine D2 agonist. It is used in the treatment of parkinson disease, particularly for alleviation of tremor. It has also been used for circulatory disorders and in other applications as a D2 agonist.

Molecular Formula

  • C16-H18-N4-O2

Molecular Weight

  • 298.344
 

Classification Codes

  • Anti-Dyskinesia Agents
  • Antiparkinson Agents
  • Central Nervous System Agents
  • Dopamine Agents
  • Dopamine Agonists
  • Drug / Therapeutic Agent
  • Neurotransmitter Agents
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Names and Synonyms

Name of Substance

  • Piribedil
  • Piribedil [INN:DCF]

MeSH Heading

  • Piribedil

Synonyms

  • 1-(2-Pyrimidyl)-4-piperonylpiperazine
  • 1-(3,4-Methylenedioxybenzyl)-4-(2-pyrimidyl)piperazine
  • 2-(4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinyl)pyrimidine
  • 2-(4-(3,4-Methylenedioxybenzyl)piperazino)pyrimidine
  • 2-(4-Piperonyl-1-piperazinyl)pyrimidine
  • BRN 0963637
  • EINECS 222-764-6
  • ET 495
  • ET-495
  • EU 4200
  • EU-4200
  • Piribedil
  • Piribedile
  • Piribedile [DCIT]
  • Piribedilum
  • Piribedilum [INN-Latin]
  • Trivastal
  • Trivastan
  • UNII-DO22K1PRDJ

Systematic Names

  • 2-(4-Piperonyl-1-piperazinyl)pyrimidine
  • Piribedil
  • Pyrimidine, 2-(4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl)-
  • Pyrimidine, 2-(4-piperonyl-1-piperazinyl)-

Registry Numbers

CAS Registry Number

  • 3605-01-4

FDA UNII

  • DO22K1PRDJ

Related Registry Numbers

  • 52293-23-9 (mesylate)
  • 78213-63-5 (mono-hydrochloride)

System Generated Number

  • 0003605014

Structure Descriptors

InChI

1S/C16H18N4O2/c1-4-17-16(18-5-1)20-8-6-19(7-9-20)11-13-2-3-14-15(10-13)22-12-21-14/h1-5,10H,6-9,11-12H2

InChIKey

OQDPVLVUJFGPGQ-UHFFFAOYSA-N

Smiles

c12c(ccc(c1)CN1CCN(c3ncccn3)CC1)OCO2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 690mg/kg (690mg/kg) VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION Journal of Medicinal Chemistry. Vol. 11, Pg. 1151, 1968.
mouse LD50 intravenous 88mg/kg (88mg/kg)   European Journal of Pharmacology. Vol. 6, Pg. 75, 1969.
mouse LD50 oral 1460mg/kg (1460mg/kg)   European Journal of Pharmacology. Vol. 6, Pg. 75, 1969.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 98 deg C   EXP
log P (octanol-water) 2.330 (none)   EST
Atmospheric OH Rate Constant 1.83E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.