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Substance Name: Piribedil [INN:DCF]
RN: 3605-01-4
UNII: DO22K1PRDJ
InChIKey: OQDPVLVUJFGPGQ-UHFFFAOYSA-N
Note
- A dopamine D2 agonist. It is used in the treatment of parkinson disease, particularly for alleviation of tremor. It has also been used for circulatory disorders and in other applications as a D2 agonist.
Molecular Formula
- C16-H18-N4-O2
Molecular Weight
- 298.344
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Anti-Dyskinesia Agents
- Antiparkinson Agents
- Central Nervous System Agents
- Dopamine Agents
- Dopamine Agonists
- Drug / Therapeutic Agent
- Neurotransmitter Agents
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Links to Resources
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Names and Synonyms
Name of Substance
- Piribedil
- Piribedil [INN:DCF]
MeSH Heading
- Piribedil
Synonyms
- 1-(2-Pyrimidyl)-4-piperonylpiperazine
- 1-(3,4-Methylenedioxybenzyl)-4-(2-pyrimidyl)piperazine
- 2-(4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinyl)pyrimidine
- 2-(4-(3,4-Methylenedioxybenzyl)piperazino)pyrimidine
- 2-(4-Piperonyl-1-piperazinyl)pyrimidine
- BRN 0963637
- EINECS 222-764-6
- ET 495
- ET-495
- EU 4200
- EU-4200
- Piribedil
- Piribedile
- Piribedile [DCIT]
- Piribedilum
- Piribedilum [INN-Latin]
- Trivastal
- Trivastan
- UNII-DO22K1PRDJ
Systematic Names
- 2-(4-Piperonyl-1-piperazinyl)pyrimidine
- Piribedil
- Pyrimidine, 2-(4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl)-
- Pyrimidine, 2-(4-piperonyl-1-piperazinyl)-
Registry Numbers
CAS Registry Number
- 3605-01-4
FDA UNII
- DO22K1PRDJ
Related Registry Numbers
- 52293-23-9 (mesylate)
- 78213-63-5 (mono-hydrochloride)
System Generated Number
- 0003605014
Structure Descriptors
InChI
InChI=1S/C16H18N4O2/c1-4-17-16(18-5-1)20-8-6-19(7-9-20)11-13-2-3-14-15(10-13)22-12-21-14/h1-5,10H,6-9,11-12H2InChIKey
OQDPVLVUJFGPGQ-UHFFFAOYSA-NSmiles
C(N1CCN(CC1)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 690mg/kg (690mg/kg) | VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION | Journal of Medicinal Chemistry. Vol. 11, Pg. 1151, 1968. |
| mouse | LD50 | intravenous | 88mg/kg (88mg/kg) | European Journal of Pharmacology. Vol. 6, Pg. 75, 1969. | |
| mouse | LD50 | oral | 1460mg/kg (1460mg/kg) | European Journal of Pharmacology. Vol. 6, Pg. 75, 1969. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 98 | deg C | EXP | |
| log P (octanol-water) | 2.330 | (none) | EST | |
| Atmospheric OH Rate Constant | 1.83E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.