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Substance Name: Talipexole dihydrochloride
RN: 36085-73-1
UNII: 9R6E1D8H1O
InChIKey: DPQAXNSOFFYKDS-UHFFFAOYSA-N

Note

  • Dopamine receptor agonist.

Molecular Formula

  • C10-H15-N3-S.2Cl-H

Molecular Weight

  • 282.2373
 

Classification Codes

  • Adrenergic Agents
  • Adrenergic Agonists
  • Adrenergic alpha-Agonists
  • Antidepressive Agents
  • Central Nervous System Agents
  • Dopamine Agents
  • Dopamine Agonists
  • Drug / Therapeutic Agent
  • Neurotransmitter Agents
  • Psychotropic Drugs
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Talipexole
  • Talipexole dihydrochloride

Synonyms

  • 2-Amino-6-allyl-4,5,7,8-tetrahydro-6H-thiazolo(5,4-d)azepin-dihydrochlorid
  • 2-Amino-6-allyl-4,5,7,8-tetrahydro-6H-thiazolo(5,4-d)azepin-dihydrochlorid [German]
  • 5,6,7,8-Tetrahydro-6-(2-propenyl)-4H-thiazolo(4,5-d)azepin-2-amine dihydrochloride
  • 6-Allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo(4,5-d)azepine dihydrochloride
  • B-HT 920
  • Talipexole dihydrochloride
  • UNII-9R6E1D8H1O

Systematic Name

  • 4H-Thiazolo(4,5-d)azepin-2-amine, 5,6,7,8-tetrahydro-6-(2-propenyl)-, dihydrochloride

Registry Numbers

CAS Registry Number

  • 36085-73-1

FDA UNII

  • 9R6E1D8H1O

System Generated Number

  • 0036085731

Molecular Formulas

Molecular Formula

  • C10-H15-N3-S.2Cl-H

Molecular Formula Fragments

  • C10-H15-N3-S
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C10H15N3S.2ClH/c1-2-5-13-6-3-8-9(4-7-13)14-10(11)12-8;;/h2H,1,3-7H2,(H2,11,12);2*1H

InChIKey

DPQAXNSOFFYKDS-UHFFFAOYSA-N

Smiles

C=CCN1CCc2c(sc(n2)N)CC1.Cl.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
monkey LD oral > 32mg/kg (32mg/kg) BEHAVIORAL: COMA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Oyo Yakuri. Pharmacometrics. Vol. 46, Pg. 401, 1993.
mouse LD50 intravenous 68mg/kg (68mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 38, Pg. 2843, 1996.
mouse LD50 oral 455mg/kg (455mg/kg)   German Offenlegungsschrift Patent Document. Vol. #2820808,
rat LD50 intravenous 66mg/kg (66mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Oyo Yakuri. Pharmacometrics. Vol. 46, Pg. 383, 1993.
rat LD50 oral 403mg/kg (403mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE

BEHAVIORAL: TREMOR
Oyo Yakuri. Pharmacometrics. Vol. 46, Pg. 383, 1993.