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Substance Name: Flurazepam monohydrochloride
RN: 36105-20-1
UNII: 7C4JH842IJ
InChIKey: PUGVROXLRUQCAF-UHFFFAOYSA-N

Note

  • A benzodiazepine derivative used mainly as a hypnotic.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C21-H23-Cl-F-N3-O.Cl-H

Molecular Weight

  • 424.3446
 
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Names and Synonyms

Results Name

  • Flurazepam monohydrochloride

Name of Substance

  • Flurazepam monohydrochloride

Synonyms

  • EINECS 252-867-1
  • Flurazepam HCl
  • Flurazepam hydrochloride
  • Flurazepam monohydrochloride
  • UNII-7C4JH842IJ

Systematic Names

  • 2H-1,4-Benzodiazepin-2-one, 7-chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1,3-dihydro-, monohydrochloride
  • 7-Chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo-1,4-diazepin-2-one monohydrochloride

Registry Numbers

CAS Registry Number

  • 36105-20-1

FDA UNII

  • 7C4JH842IJ

Related Registry Number

  • 17617-23-1 (Parent)

System Generated Number

  • 0036105201

Molecular Formulas

Molecular Formula

  • C21-H23-Cl-F-N3-O.Cl-H

Molecular Formula Fragments

  • C21-H23-Cl-F-N3-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C21H23ClFN3O.ClH/c1-3-25(4-2)11-12-26-19-10-9-15(22)13-17(19)21(24-14-20(26)27)16-7-5-6-8-18(16)23;/h5-10,13H,3-4,11-12,14H2,1-2H3;1H

InChIKey

PUGVROXLRUQCAF-UHFFFAOYSA-N

Smiles

c12c(N(C(=O)CN=C1c1c(cccc1)F)CCN(CC)CC)ccc(c2)Cl.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 205mg/kg (205mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 381, 1973.
mouse LD50 intravenous 58mg/kg (58mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 381, 1973.
mouse LD50 oral 684mg/kg (684mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 2820, 1973.
mouse LD50 subcutaneous 598mg/kg (598mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 2820, 1973.
rabbit LD50 oral 460mg/kg (460mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 2820, 1973.
rat LD50 intraperitoneal 179mg/kg (179mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 2820, 1973.
rat LD50 intravenous 40mg/kg (40mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 2820, 1973.
rat LD50 oral 978mg/kg (978mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 2820, 1973.
rat LD50 subcutaneous 859mg/kg (859mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 2820, 1973.