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Substance Name: Dimethindene maleate [USAN:USP]
RN: 3614-69-5
UNII: 6LL60J9E0O
InChIKey: SWECWXGUJQLXJF-BTJKTKAUSA-N

Note

  • A histamine H1 antagonist. It is used in hypersensitivity reactions, in rhinitis, for pruritus, and in some common cold remedies.

Molecular Formula

  • C20-H24-N2.C4-H4-O4

Molecular Weight

  • 408.495
 

Classification Codes

  • Antihistaminic
  • Drug / Therapeutic Agent
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Names and Synonyms

Name of Substance

  • Dimethindene maleate [USAN:USP]

Synonyms

  • 1H-Indene-2-ethanamine, N,N-dimethyl-3-(1-(2-pyridinyl)ethyl)-, (Z)-2-butenedioate (1:1)
  • 2-(1-(2-(2-(Dimethylamino)ethyl)inden-3-yl)ethyl)pyridine maleate
  • 2-(1-(2-(2-(Dimethylamino)ethyl)inden-3-yl)ethyl)pyridine maleate (1:1)
  • Dimethinden maleate
  • Dimethindene maleate
  • Dimethpyrindene maleate
  • Dimetindene maleate
  • EINECS 222-789-2
  • Fenistil
  • Fenistil-retard
  • Forhistal maleate
  • NSC 107677
  • SU 6518
  • SU-6518
  • UNII-6LL60J9E0O

Systematic Names

  • 1H-Indene-2-ethanamine, N,N-dimethyl-3-(1-(2-pyridinyl)ethyl)-, (Z)-2-butenedioate (1:1)
  • Dimetindene hydrogen maleate
  • Pyridine, 2-(1-(2-(2-(dimethylamino)ethyl)inden-3-yl)ethyl)-, maleate (1:1)

Registry Numbers

CAS Registry Number

  • 3614-69-5

FDA UNII

  • 6LL60J9E0O

Related Registry Number

  • 5636-83-9 (Parent)

System Generated Number

  • 0003614695

Molecular Formulas

Molecular Formula

  • C20-H24-N2.C4-H4-O4

Molecular Formula Fragments

  • C20-H24-N2
  • C4-H4-O4
  • COMPONENT

Structure Descriptors

InChI

1S/C20H24N2.C4H4O4/c1-15(19-10-6-7-12-21-19)20-17(11-13-22(2)3)14-16-8-4-5-9-18(16)20;5-3(6)1-2-4(7)8/h4-10,12,15H,11,13-14H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChIKey

SWECWXGUJQLXJF-BTJKTKAUSA-N

Smiles

C1(=C(Cc2c1cccc2)CCN(C)C)[C@@H](c1ncccc1)C.C(\C=C/C(=O)O)(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 50mg/kg (50mg/kg)   Toxicology and Applied Pharmacology. Vol. 3, Pg. 534, 1961.
guinea pig LD50 oral 888mg/kg (888mg/kg)   Toxicology and Applied Pharmacology. Vol. 3, Pg. 534, 1961.
rat LD50 intravenous 26800ug/kg (26.8mg/kg)   Toxicology and Applied Pharmacology. Vol. 3, Pg. 534, 1961.
rat LD50 oral 618mg/kg (618mg/kg)   Toxicology and Applied Pharmacology. Vol. 3, Pg. 534, 1961.