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Substance Name: Diamfenetide [INN:BAN]
RN: 36141-82-9
UNII: U4TFJ7GB6T
InChIKey: JNEZCZPNQCQCFK-UHFFFAOYSA-N

Note

  • Anthelmintic. It has been shown to be useful in fasciola infections in sheep.

Molecular Formula

  • C20-H24-N2-O5

Molecular Weight

  • 372.419
 

Classification Codes

  • Anthelmintics
  • Anti-Infective Agents
  • Antiparasitic Agents
  • Antiplatyhelmintic Agents
  • Mutation Data
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Names and Synonyms

Name of Substance

  • Diamfenetide
  • Diamfenetide [INN:BAN]

MeSH Heading

  • Diamfenetide

Synonyms

  • 4,4'-Oxybis(ethylenoxy)bis(acetanilid)
  • 4-13-00-01099 (Beilstein Handbook Reference)
  • Acemidophene
  • beta,beta'-Oxybis(p-acetophenetidide)
  • BRN 2179741
  • Compound 68-198
  • Coryphamin
  • Diamfenetida
  • Diamfenetida [INN-Spanish]
  • Diamfenetide
  • Diamfenetidum
  • Diamfenetidum [INN-Latin]
  • EINECS 252-886-5
  • N,N'-(Oxybis(2,1-ethanediyloxy-4,1-phenylene))bisacetamide
  • NSC 291838
  • UNII-U4TFJ7GB6T
  • WR 219124

Systematic Names

  • Acetamide, N,N'-(oxybis(2,1-ethanediyloxy-4,1-phenylene))bis-
  • beta,beta'-Oxybis(p-acetophenetidide)
  • Diamfenetide

Registry Numbers

CAS Registry Number

  • 36141-82-9

FDA UNII

  • U4TFJ7GB6T

System Generated Number

  • 0036141829

Structure Descriptors

InChI

1S/C20H24N2O5/c1-15(23)21-17-3-7-19(8-4-17)26-13-11-25-12-14-27-20-9-5-18(6-10-20)22-16(2)24/h3-10H,11-14H2,1-2H3,(H,21,23)(H,22,24)

InChIKey

JNEZCZPNQCQCFK-UHFFFAOYSA-N

Smiles

c1(ccc(NC(C)=O)cc1)OCCOCCOc1ccc(NC(C)=O)cc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 6300mg/kg (6300mg/kg)   Cytology and Genetics Vol. 22(4), Pg. 59, 1988.
mouse LD50 oral 20gm/kg (20000mg/kg)   Cytology and Genetics Vol. 22(4), Pg. 59, 1988.
rat LD50 intraperitoneal 6300mg/kg (6300mg/kg)   Cytology and Genetics Vol. 22(4), Pg. 59, 1988.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 1.750 (none)   EST
Atmospheric OH Rate Constant 5.07E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.