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Substance Name: Halofantrine Hydrochloride [USAN]
RN: 36167-63-2
UNII: H77DL0Y630
InChIKey: WANGFTDWOFGECH-UHFFFAOYSA-N

Note

  • Used in treatment of mild to moderate acute malaria.

Molecular Formula

  • C26-H30-Cl2-F3-N-O.Cl-H

Molecular Weight

  • 536.8899
 

Classification Codes

  • Anti-Infective Agents
  • Antimalarial
  • Antimalarials
  • Antiparasitic Agents
  • Antiprotozoal Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Halofantrine
  • Halofantrine Hydrochloride [USAN]

Synonyms

  • (+-)-Halofantrine hydrochloride
  • 1,3-Dichloro-6-trifluoromethyl-9-(3-(dibutylamino)-1-hydroxypropyl)phenanthrene HCl
  • 1,3-Dichloro-alpha-(2-(dibutylamino)ethyl)-6-(trifluoromethyl)-9-phenanthrenemethanol hydrochloride
  • 1-(1,3-Dichloro-6-trifluoromethyl-9-phenanthryl)-3-(di-n-butylamino)propanol hydrochloride
  • 9-(3-(dibutylamino)-1-hydroxypropyl)-1,3-dichloro-6-(trifluoromethyl)phenanthrene hydrochloride
  • 9-Phenanthrenemethanol, 1,3-dichloro-alpha-(2-(dibutylamino)ethyl)-6-(trifluoromethyl)-, hydrochloride
  • EINECS 252-895-4
  • Halfan
  • Halofantrine hydrochloride
  • Halofantrino
  • Halofantrino [Spanish]
  • SKF 102886
  • UNII-H77DL0Y630
  • WR 171669
  • WR-171,669
  • WR-171669

Systematic Names

  • 1,3-Dichloro-alpha-(2-(dibutylamino)ethyl)-6-(trifluoromethyl)phenanthren-1-methanol hydrochloride
  • 9-Phenanthrenemethanol, 1,3-dichloro-alpha-(2-(dibutylamino)ethyl)-6-(trifluoromethyl)-, hydrochloride

Registry Numbers

CAS Registry Number

  • 36167-63-2

FDA UNII

  • H77DL0Y630

Other Registry Number

  • 106927-11-1

System Generated Number

  • 0036167632

Molecular Formulas

Molecular Formula

  • C26-H30-Cl2-F3-N-O.Cl-H

Molecular Formula Fragments

  • C26-H30-Cl2-F3-N-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C26H30Cl2F3NO.ClH/c1-3-5-10-32(11-6-4-2)12-9-25(33)23-16-22-21(14-18(27)15-24(22)28)20-13-17(26(29,30)31)7-8-19(20)23;/h7-8,13-16,25,33H,3-6,9-12H2,1-2H3;1H

InChIKey

WANGFTDWOFGECH-UHFFFAOYSA-N

Smiles

Cl.CCCCN(CCCC)CCC(O)c1cc2c(Cl)cc(Cl)cc2c3cc(ccc13)C(F)(F)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 7143ug/kg (7.143mg/kg) LIVER: LIVER FUNCTION TESTS IMPAIRED

KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED

KIDNEY, URETER, AND BLADDER: HEMATURIA
Lancet. Vol. 340, Pg. 909, 1992.
man TDLo oral 7143ug/kg (7.143mg/kg) LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED"

BLOOD: OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA

KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED
Lancet. Vol. 340, Pg. 909, 1992.
man TDLo oral 18mg/kg/D (18mg/kg) GASTROINTESTINAL: OTHER CHANGES

GASTROINTESTINAL: NAUSEA OR VOMITING
Drugs of the Future. Vol. 5, Pg. 547, 1980.
rat LD50 intraperitoneal 2050mg/kg (2050mg/kg)   Acta Tropica. Vol. 37, Pg. 232, 1980.
rat LD50 intraperitoneal 2050mg/kg (2050mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING Acta Tropica. Vol. 37, Pg. 232, 1980.
rat LD50 oral 3400mg/kg (3400mg/kg)   Acta Tropica. Vol. 37, Pg. 232, 1980.
rat LD50 oral 3400mg/kg (3400mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING Acta Tropica. Vol. 37, Pg. 232, 1980.
women LDLo oral 72mg/kg/3D-I (72mg/kg) CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION Lancet. Vol. 341, Pg. 1054, 1993.