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Substance Name: Dimemorfan phosphate
RN: 36304-84-4
UNII: S203Y5Y1QP
InChIKey: ODJHDWLIOUGPPA-URVXVIKDSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C18-H25-N.H3-O4-P

Molecular Weight

  • 353.3962
 
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Names and Synonyms

Results Name

  • Dimemorfan phosphate

Name of Substance

  • Dimemorfan phosphate [JAN]

Synonyms

  • (9-alpha,13-alpha,14-alpha)-3,17-Dimethylmorphinan phosphate
  • 3,17-Dimethyl-9-alpha,13-alpha,14-alpha-morphinan phosphate
  • Astomin
  • AT-17 phosphate
  • d-3-Methyl-N-methylmorphinan phosphate
  • Dimemorfan phosphate
  • EINECS 252-958-6
  • Gentus
  • UNII-S203Y5Y1QP

Systematic Names

  • (9alpha,13alpha,14alpha)-3,17-Dimethylmorphinan dihydrogen phosphate
  • Morphinan, 3,17-dimethyl-, (9-alpha,13-alpha,14-alpha)-, phosphate (1:1)

Registry Numbers

CAS Registry Number

  • 36304-84-4

FDA UNII

  • S203Y5Y1QP

Related Registry Number

  • 36304-82-2 (Parent)

System Generated Number

  • 0036304844

Molecular Formulas

Molecular Formula

  • C18-H25-N.H3-O4-P

Molecular Formula Fragments

  • C18-H25-N
  • COMPONENT
  • H3-O4-P

Structure Descriptors

InChI

1S/C18H25N.H3O4P/c1-13-6-7-14-12-17-15-5-3-4-8-18(15,16(14)11-13)9-10-19(17)2;1-5(2,3)4/h6-7,11,15,17H,3-5,8-10,12H2,1-2H3;(H3,1,2,3,4)/t15-,17+,18+;/m1./s1

InChIKey

ODJHDWLIOUGPPA-URVXVIKDSA-N

Smiles

Cc1ccc2c(c1)[C@]34CCCC[C@@H]3[C@H](C2)N(CC4)C.OP(=O)(O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 intravenous 22600ug/kg (22.6mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1207, 1972.
dog LD50 intravenous 35mg/kg (35mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR

GASTROINTESTINAL: NAUSEA OR VOMITING
Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 353, 1976.
guinea pig LD50 oral 528mg/kg (528mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1207, 1972.
guinea pig LD50 subcutaneous 180mg/kg (180mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1207, 1972.
mouse LD50 intravenous 33900ug/kg (33.9mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1207, 1972.
mouse LD50 oral 475mg/kg (475mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR

BEHAVIORAL: ATAXIA
Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 353, 1976.
mouse LD50 subcutaneous 202mg/kg (202mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Japan Medical Gazette. Vol. 11(12), Pg. 13, 1974.
rat LD50 intraperitoneal 124mg/kg (124mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1207, 1972.
rat LD50 intravenous 57500ug/kg (57.5mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1207, 1972.
rat LD50 oral 690mg/kg (690mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1207, 1972.
rat LD50 subcutaneous 556mg/kg (556mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Japan Medical Gazette. Vol. 11(12), Pg. 13, 1974.