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Substance Name: Phosphoramidon
RN: 36357-77-4
UNII: T3G94E2LB1
InChIKey: ZPHBZEQOLSRPAK-XLCYBJAPSA-N

Note

  • A membrane metallo-endopeptidase & endothelin-converting enzyme inhibitor; thermolysin inhibitor from culture filtrate of Streptomyces tanashiensis.

Molecular Formula

  • C23-H34-N3-O10-P

Molecular Weight

  • 543.5066
 

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Protease Inhibitors
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Names and Synonyms

Name of Substance

  • Phosphoramidon

Synonyms

  • EINECS 252-996-3
  • N-(N-(((6-Deoxy-alpha-L-mannopyranosyl)oxy)hydroxyphosphinyl)-L-leucyl)-L-tryptophan
  • Phosphoramidon
  • UNII-T3G94E2LB1

Systematic Names

  • L-Tryptophan, N-(N-(((6-deoxy-alpha-L-mannopyranosyl)oxy)hydroxyphosphinyl)-L-leucyl)-
  • N-(N-(((6-Deoxy-alpha-L-mannopyranosyl)oxy)hydroxyphosphinyl)-L-leucyl)-L-tryptophan

Registry Numbers

CAS Registry Number

  • 36357-77-4

FDA UNII

  • T3G94E2LB1

System Generated Number

  • 0036357774

Structure Descriptors

InChI

1S/C23H34N3O10P/c1-11(2)8-16(26-37(33,34)36-23-20(29)19(28)18(27)12(3)35-23)21(30)25-17(22(31)32)9-13-10-24-15-7-5-4-6-14(13)15/h4-7,10-12,16-20,23-24,27-29H,8-9H2,1-3H3,(H,25,30)(H,31,32)(H2,26,33,34)/t12-,16-,17-,18-,19+,20+,23-/m0/s1

InChIKey

ZPHBZEQOLSRPAK-XLCYBJAPSA-N

Smiles

CC(C)C[C@H](NP(=O)(O)O[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD intravenous > 1gm/kg (1000mg/kg)   Journal of Antibiotics. Vol. 26, Pg. 621, 1973.