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Substance Name: Diazoxide [USAN:USP:INN:BAN:JAN]
RN: 364-98-7
UNII: O5CB12L4FN
InChIKey: GDLBFKVLRPITMI-UHFFFAOYSA-N

Note

  • A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.

Molecular Formula

  • C8-H7-Cl-N2-O2-S

Molecular Weight

  • 230.6743
 

Classification Codes

  • Antihypertensive
  • Antihypertensive Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Reproductive Effect
  • Vasodilator Agents
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Names and Synonyms

Name of Substance

  • Diazoxide
  • Diazoxide [USAN:USP:INN:BAN:JAN]

MeSH Heading

  • Diazoxide

Synonyms

  • 7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
  • 7-Cloro-3-metil-2H-1,2,4-benzotiodiazina-1,1-diossido
  • 7-Cloro-3-metil-2H-1,2,4-benzotiodiazina-1,1-diossido [Italian]
  • Diazossido
  • Diazossido [DCIT]
  • Diazossido [Italian]
  • Diazoxide
  • Diazoxido
  • Diazoxido [INN-Spanish]
  • Diazoxidum
  • Diazoxidum [INN-Latin]
  • Dizoxide
  • EINECS 206-668-1
  • Eudemine
  • Hyperstat
  • Hypertonalum
  • Mutabase
  • NSC 64198
  • NSC 76130
  • Proglicem
  • Proglycem
  • Sch 6783
  • SRG 95213
  • UNII-O5CB12L4FN

Systematic Names

  • 2H-1,2,4-Benzothiadiazine, 7-chloro-3-methyl-, 1,1-dioxide
  • Diazoxide

Superlist Name

  • Diazoxide

Registry Numbers

CAS Registry Number

  • 364-98-7

FDA UNII

  • O5CB12L4FN

Other Registry Number

  • 1342899-70-0

System Generated Number

  • 0000364987

Structure Descriptors

InChI

1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)

InChIKey

GDLBFKVLRPITMI-UHFFFAOYSA-N

Smiles

c12c(S(NC(=N1)C)(=O)=O)cc(Cl)cc2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 326mg/kg (326mg/kg) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION Journal of Pharmacology and Experimental Therapeutics. Vol. 136, Pg. 344, 1962.
mouse LD50 intravenous 228mg/kg (228mg/kg) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION Journal of Pharmacology and Experimental Therapeutics. Vol. 136, Pg. 344, 1962.
mouse LD50 oral 444mg/kg (444mg/kg) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION Journal of Pharmacology and Experimental Therapeutics. Vol. 136, Pg. 344, 1962.
rat LD50 intraperitoneal 510mg/kg (510mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 143, Pg. 446, 1963.
rat LD50 oral 980mg/kg (980mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 143, Pg. 446, 1963.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 330.5 deg C   EXP
pKa Dissociation Constant 8.74 (none)   EXP
log P (octanol-water) 1.2 (none)   EXP
Water Solubility 2850 mg/L 25 EST
Vapor Pressure 2.88E-08 mm Hg 25 EST
Henry's Law Constant 6.85E-08 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 4.89E-13 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.