|
|
|
Substance Name: Diazoxide [USAN:USP:INN:BAN:JAN]
RN: 364-98-7
UNII: O5CB12L4FN
InChIKey: GDLBFKVLRPITMI-UHFFFAOYSA-N
Note
- A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
Molecular Formula
- C8-H7-Cl-N2-O2-S
Molecular Weight
- 230.6743
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Antihypertensive
- Antihypertensive Agents
- Cardiovascular Agents
- Drug / Therapeutic Agent
- Reproductive Effect
- Vasodilator Agents
* denotes mobile formatted website
Links to Resources
NLM Resources (File Locators)
Regulatory Agencies (Superlist Locators)
Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- Diazoxide
- Diazoxide [USAN:USP:INN:BAN:JAN]
MeSH Heading
- Diazoxide
Synonyms
- 7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
- 7-Cloro-3-metil-2H-1,2,4-benzotiodiazina-1,1-diossido
- 7-Cloro-3-metil-2H-1,2,4-benzotiodiazina-1,1-diossido [Italian]
- Diazossido
- Diazossido [DCIT]
- Diazossido [Italian]
- Diazoxide
- Diazoxido
- Diazoxido [INN-Spanish]
- Diazoxidum
- Diazoxidum [INN-Latin]
- Dizoxide
- EINECS 206-668-1
- Eudemine
- Hyperstat
- Hypertonalum
- Mutabase
- NSC 64198
- NSC 76130
- Proglicem
- Proglycem
- Sch 6783
- SRG 95213
- UNII-O5CB12L4FN
Systematic Names
- 2H-1,2,4-Benzothiadiazine, 7-chloro-3-methyl-, 1,1-dioxide
- Diazoxide
Superlist Name
- Diazoxide
Registry Numbers
CAS Registry Number
- 364-98-7
FDA UNII
- O5CB12L4FN
Other Registry Number
- 1342899-70-0
System Generated Number
- 0000364987
Structure Descriptors
InChI
1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)InChIKey
GDLBFKVLRPITMI-UHFFFAOYSA-NSmiles
c12c(S(NC(=N1)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 326mg/kg (326mg/kg) | VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION | Journal of Pharmacology and Experimental Therapeutics. Vol. 136, Pg. 344, 1962. |
| mouse | LD50 | intravenous | 228mg/kg (228mg/kg) | VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION | Journal of Pharmacology and Experimental Therapeutics. Vol. 136, Pg. 344, 1962. |
| mouse | LD50 | oral | 444mg/kg (444mg/kg) | VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION | Journal of Pharmacology and Experimental Therapeutics. Vol. 136, Pg. 344, 1962. |
| rat | LD50 | intraperitoneal | 510mg/kg (510mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 143, Pg. 446, 1963. | |
| rat | LD50 | oral | 980mg/kg (980mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 143, Pg. 446, 1963. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 330.5 | deg C | EXP | |
| pKa Dissociation Constant | 8.74 | (none) | EXP | |
| log P (octanol-water) | 1.2 | (none) | EXP | |
| Water Solubility | 2850 | mg/L | 25 | EST |
| Vapor Pressure | 2.88E-08 | mm Hg | 25 | EST |
| Henry's Law Constant | 6.85E-08 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 4.89E-13 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.