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Substance Name: Diazoxide [USAN:USP:INN:BAN:JAN]
RN: 364-98-7
UNII: O5CB12L4FN
InChIKey: GDLBFKVLRPITMI-UHFFFAOYSA-N
Note
- A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
Molecular Formula
- C8-H7-Cl-N2-O2-S
Molecular Weight
- 230.6743
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Antihypertensive
- Antihypertensive Agents
- Cardiovascular Agents
- Drug / Therapeutic Agent
- Reproductive Effect
- Vasodilator Agents
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Names and Synonyms
Name of Substance
- Diazoxide
- Diazoxide [USAN:USP:INN:BAN:JAN]
MeSH Heading
- Diazoxide
Synonyms
- 7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
- 7-Cloro-3-metil-2H-1,2,4-benzotiodiazina-1,1-diossido
- 7-Cloro-3-metil-2H-1,2,4-benzotiodiazina-1,1-diossido [Italian]
- Diazossido
- Diazossido [DCIT]
- Diazossido [Italian]
- Diazoxide
- Diazoxido
- Diazoxido [INN-Spanish]
- Diazoxidum
- Diazoxidum [INN-Latin]
- Dizoxide
- EINECS 206-668-1
- Eudemine
- Hyperstat
- Hypertonalum
- Mutabase
- NSC 64198
- NSC 76130
- Proglicem
- Proglycem
- Sch 6783
- SRG 95213
- UNII-O5CB12L4FN
Systematic Names
- 2H-1,2,4-Benzothiadiazine, 7-chloro-3-methyl-, 1,1-dioxide
- Diazoxide
Superlist Name
- Diazoxide
Registry Numbers
CAS Registry Number
- 364-98-7
FDA UNII
- O5CB12L4FN
Other Registry Number
- 1342899-70-0
System Generated Number
- 0000364987
Structure Descriptors
InChI
InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)InChIKey
GDLBFKVLRPITMI-UHFFFAOYSA-NSmiles
CC1=Nc2ccc(Cl)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 326mg/kg (326mg/kg) | VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION | Journal of Pharmacology and Experimental Therapeutics. Vol. 136, Pg. 344, 1962. |
| mouse | LD50 | intravenous | 228mg/kg (228mg/kg) | VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION | Journal of Pharmacology and Experimental Therapeutics. Vol. 136, Pg. 344, 1962. |
| mouse | LD50 | oral | 444mg/kg (444mg/kg) | VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION | Journal of Pharmacology and Experimental Therapeutics. Vol. 136, Pg. 344, 1962. |
| rat | LD50 | intraperitoneal | 510mg/kg (510mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 143, Pg. 446, 1963. | |
| rat | LD50 | oral | 980mg/kg (980mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 143, Pg. 446, 1963. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 330.5 | deg C | EXP | |
| pKa Dissociation Constant | 8.74 | (none) | EXP | |
| log P (octanol-water) | 1.2 | (none) | EXP | |
| Water Solubility | 2850 | mg/L | 25 | EST |
| Vapor Pressure | 2.88E-08 | mm Hg | 25 | EST |
| Henry's Law Constant | 6.85E-08 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 4.89E-13 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.