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Substance Name: Tolperisone hydrochloride [JAN]
RN: 3644-61-9
UNII: 8Z075K2TIG
InChIKey: ZBUVYROEHQQAKL-UHFFFAOYSA-N

Note

  • A centrally acting muscle relaxant that has been used for the symptomatic treatment of spasticity and muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1211)

Molecular Formula

  • C16-H23-N-O.Cl-H

Molecular Weight

  • 281.8246
 

Classification Code

  • Drug / Therapeutic Agent
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Names and Synonyms

Name of Substance

  • Tolperisone hydrochloride [JAN]

Synonyms

  • 1-Piperidino-2-methyl-3-(p-tolyl)-3-propanone hydrochloride
  • 1-Propanone, 2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-, hydrochloride
  • 2,4'-Dimethyl-3-piperidinopropiophenone hydrochloride
  • 2-Methyl-3-piperidino-1-p-tolylpropan-1-one hydrochloride
  • AV 650
  • EINECS 222-876-5
  • Midocalm
  • Muscalm
  • Mydocalm
  • N-553
  • Tolperisone HCl
  • Tolperisone hydrochloride
  • UNII-8Z075K2TIG

Systematic Names

  • 2,4'-Dimethyl-3-piperidinopropiophenone hydrochloride
  • Propiophenone, 2,4'-dimethyl-3-piperidino-, hydrochloride

Registry Numbers

CAS Registry Number

  • 3644-61-9

FDA UNII

  • 8Z075K2TIG

System Generated Number

  • 0003644619

Molecular Formulas

Molecular Formula

  • C16-H23-N-O.Cl-H

Molecular Formula Fragments

  • C16-H23-N-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C16H23NO.ClH/c1-13-6-8-15(9-7-13)16(18)14(2)12-17-10-4-3-5-11-17;/h6-9,14H,3-5,10-12H2,1-2H3;1H

InChIKey

ZBUVYROEHQQAKL-UHFFFAOYSA-N

Smiles

Cc1ccc(cc1)C(=O)C(C)CN2CCCCC2.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 intravenous 40mg/kg (40mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 809, 1975.
dog LD50 intravenous 45mg/kg (45mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 809, 1975.
mouse LD50 intraperitoneal 210mg/kg (210mg/kg)   United States Patent Document. Vol. #4528299,
mouse LD50 intravenous 34mg/kg (34mg/kg)   Yakkyoku. Pharmacy. Vol. 24, Pg. 1637, 1973.
mouse LD50 oral 358mg/kg (358mg/kg)   Yakugaku Zasshi. Journal of Pharmacy. Vol. 107, Pg. 705, 1987.
mouse LD50 subcutaneous 655mg/kg (655mg/kg)   Yakkyoku. Pharmacy. Vol. 24, Pg. 1637, 1973.
rat LD50 intraperitoneal 170mg/kg (170mg/kg)   Drugs in Japan Vol. 6, Pg. 531, 1982.
rat LD50 oral 1450mg/kg (1450mg/kg)   Drugs in Japan Vol. 6, Pg. 531, 1982.
rat LD50 subcutaneous 645mg/kg (645mg/kg)   Drugs in Japan Vol. 6, Pg. 531, 1982.