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Substance Name: Cinacalcet hydrochloride [USAN]
RN: 364782-34-3
UNII: 1K860WSG25
InChIKey: QANQWUQOEJZMLL-PKLMIRHRSA-N

Note

  • A naphthalene derivative and CALCIMIMETIC AGENT that increases the sensitivity of PARATHYROID GLAND calcium-sensing receptors to serum calcium. This action reduces parathyroid hormone secretion and decreases serum calcium in the treatment of PARATHYROID DISEASES.

Molecular Formula

  • C22-H22-F3-N.Cl-H

Molecular Weight

  • 393.878
 

Classification Codes

  • Calcimimetic Agents
  • Hormone Antagonists
  • Hormones, Hormone Substitutes, and Hormone Antagonists
  • Treatment of Hyperparathyroidism and Related Disorders, such as Hypercalcemia (Reduction of PTH Secretion Through Modulation of Calcium Ion Receptors on Parathyroid Cells)

Names and Synonyms

Name of Substance

  • Cinacalcet
  • Cinacalcet hydrochloride [USAN]

MeSH Heading

  • Cinacalcet Hydrochloride

Synonyms

  • 1-Naphthalenemethanamine, alpha-methyl-N-(3-(3-(trifluoromethyl)phenyl)propyl)-, (alphaR)-, hydrochloride
  • AMG 073 HCl
  • AMG073 HCl
  • Cinacalcet HCl
  • Cinacalcet hydrochloride
  • KRN 1493
  • Mimpara
  • N-((1R)-1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine hydrochloride
  • Regpara
  • Sensipar
  • UNII-1K860WSG25

Systematic Name

  • 1-Naphthalenemethanamine, alpha-methyl-N-(3-(3-(trifluoromethyl)phenyl)propyl)-, (alphaR)-, hydrochloride

Registry Numbers

CAS Registry Number

  • 364782-34-3

FDA UNII

  • 1K860WSG25

Related Registry Number

  • 226256-56-0 (Parent)

System Generated Number

  • 0364782343

Molecular Formulas

Molecular Formula

  • C22-H22-F3-N.Cl-H

Molecular Formula Fragments

  • C22-H22-F3-N
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C22H22F3N.ClH/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25;/h2-5,7,9-13,15-16,26H,6,8,14H2,1H3;1H/t16-;/m1./s1

InChIKey

QANQWUQOEJZMLL-PKLMIRHRSA-N

Smiles

c1cccc2cccc(c12)[C@H](NCCCc1cc(C(F)(F)F)ccc1)C.Cl