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Substance Name: Buspirone [INN:BAN]
RN: 36505-84-7
UNII: TK65WKS8HL
InChIKey: QWCRAEMEVRGPNT-UHFFFAOYSA-N
Note
- An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the BENZODIAZAPINES, but it has an efficacy comparable to DIAZEPAM.
Molecular Formula
- C21-H31-N5-O2
Molecular Weight
- 385.5089
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Anti-Anxiety Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- Drug / Therapeutic Agent
- Human Data
- Neurotransmitter Agents
- Psychotropic Drugs
- Serotonin Agents
- Serotonin Receptor Agonists
- Tranquilizing Agents
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Links to Resources
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Names and Synonyms
Name of Substance
- Buspirone
- Buspirone [INN:BAN]
MeSH Heading
- Buspirone
Synonyms
- 5-25-10-00059 (Beilstein Handbook Reference)
- 8-(4-(4-(2-Pyrimidinyl)-1-piperizinyl)butyl)-8-azaspiro(4,5)decane-7,9-dione
- Ansial
- BRN 0964904
- Buspirona
- Buspirona [INN-Spanish]
- Buspirone
- Buspironum
- Buspironum [INN-Latin]
- EINECS 253-072-2
- UNII-TK65WKS8HL
Systematic Names
- 8-Azaspiro(4,5)decane-7,9-dione, 8-(4-(4-(2-pyrimidinyl)piperizinyl)butyl)-
- 8-Azaspiro(4.5)decane-7,9-dione, 8-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-
- Buspirone
Registry Numbers
CAS Registry Number
- 36505-84-7
FDA UNII
- TK65WKS8HL
System Generated Number
- 0036505847
Structure Descriptors
InChI
InChI=1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2InChIKey
QWCRAEMEVRGPNT-UHFFFAOYSA-NSmiles
O=C1CC2(CCCC2)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| human | TDLo | unreported | 399mg/kg/19D- (399mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Drugs of the Future. Vol. 1, Pg. 409, 1976. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| log P (octanol-water) | 2.63 | (none) | EXP | |
| Water Solubility | 21.4 | mg/L | 25 | EST |
| Vapor Pressure | 8.17E-13 | mm Hg | 25 | EST |
| Henry's Law Constant | 1.54E-13 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 1.65E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.