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Substance Name: Ikarugamycin
RN: 36531-78-9
InChIKey: WSUGGLXIPUHOSG-KUAUWNFESA-N

Note

  • An antiprotozoal antibiotic isolated from Streptomyces phaeochromogenes ikaruganensis; inhibits the uptake of oxidized LDL in macrophage J774.

Classification Codes

  • Drug / Therapeutic Agent
  • Natural Product

Molecular Formula

  • C29-H38-N2-O4

Molecular Weight

  • 478.629
 
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Names and Synonyms

Name of Substance

  • Ikarugamycin

Systematic Name

  • Ikarugamycin

Registry Numbers

CAS Registry Number

  • 36531-78-9

System Generated Number

  • 0036531789

Structure Descriptors

InChI

1S/C29H38N2O4/c1-3-18-16(2)14-22-20(18)10-11-21-19-6-4-8-26(33)30-13-5-7-24-28(34)27(29(35)31-24)25(32)12-9-17(19)15-23(21)22/h4,8-12,16-24,34H,3,5-7,13-15H2,1-2H3,(H,30,33)(H,31,35)/b8-4+,12-9+

InChIKey

WSUGGLXIPUHOSG-KUAUWNFESA-N

Smiles

C1CCNC(C=CC[C@@H]2[C@@H](C[C@@H]3[C@@H]2C=C[C@@H]2[C@@H]3C[C@@H]([C@@H]2CC)C)C=CC(C2=C([C@@H]1NC2=O)O)=O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 6mg/kg (6mg/kg)   Journal of Antibiotics. Vol. 25, Pg. 271, 1972.
mouse LD50 intravenous 2mg/kg (2mg/kg)   Journal of Antibiotics. Vol. 25, Pg. 271, 1972.
mouse LD50 oral > 500mg/kg (500mg/kg)   Journal of Antibiotics. Vol. 25, Pg. 271, 1972.
mouse LD50 subcutaneous > 250mg/kg (250mg/kg)   Journal of Antibiotics. Vol. 25, Pg. 271, 1972.