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Substance Name: Procarbazine hydrochloride [USAN:USP:JAN]
RN: 366-70-1
UNII: XH0NPH5ZX8
InChIKey: DERJYEZSLHIUKF-UHFFFAOYSA-N

Note

  • An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.

Molecular Formulas

  • C12-H19-N3-O.Cl-H
  • C12-H9-N3-O.Cl-H

Molecular Weight

  • 257.763
 

Classification Codes

Classification Codes

  • Antineoplastic
  • Drug / Therapeutic Agent
  • Mutation Data
  • Reproductive Effect
  • Tumor Data

Superlist Classification Codes

  • Overall Carcinogenic Evaluation: Group 2A
  • Reasonably Anticipated to be a Carcinogen
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Names and Synonyms

Name of Substance

  • Procarbazine hydrochloride [USAN:USP:JAN]

Synonyms

  • 1-(p-Isopropylcarbamoylbenzyl)-2-methylhydrazine hydrochloride
  • 1-Methyl-2-(p-isopropylcarbamoylbenzyl)hydrazine hydrochloride
  • 1-Methyl-2-p-(isopropylcarbamoyl)benzohydrazine hydrochloride
  • 2-(p-(Isopropylcarbamoyl)benzyl)-1-methylhydrazine hydrochloride
  • AI3-50844
  • Benzamide, N-(1-methylethyl)-4-((2-methylhydrazino)methyl)-, monohydrochloride
  • CCRIS 531
  • Chlorhydrate de 1-methyl 2 p (isopropylcarbamoyl)benzyl-hydrazine
  • Chlorhydrate de 1-methyl 2 p (isopropylcarbamoyl)benzyl-hydrazine [French]
  • EINECS 206-678-6
  • Ibenzmethyzin
  • Ibenzmethyzin hydrochloride
  • Ibenzmethyzine hydrochloride
  • Matulane
  • MBH
  • MIH
  • MIH hydrochloride
  • N-Isopropyl-alpha-(2-methylhydrazino)-p-toluamide hydrochloride
  • N-Isopropyl-alpha-(2-methylhydrazino)-p-toluamide monohydrochloride
  • N-Isopropyl-p-(2-methylhydrazinomethyl)benzamide hydrochloride
  • Nathulane
  • Natulan hydrochloride
  • Natunalar
  • NCI-C01810
  • NSC 77213
  • NSC-77213
  • p-(N'-Methylhydrazinomethyl)-N-isopropylbenzamide hydrochloride
  • p-Toluamide, N-isopropyl-alpha-(2-methylhydrazino)-, hydrochloride
  • PCB hydrochloride
  • Procarbazine chloridrate
  • Procarbazine HCl
  • Procarbazine hydrochloride
  • Ro 4-6467/1
  • UNII-XH0NPH5ZX8

Systematic Names

  • Benzamide, N-(1-methylethyl)-4-((2-methylhydrazino)methyl)-, monohydrochloride
  • p-Toluamide, N-isopropyl-alpha-(2-methylhydrazino)-, monohydrochloride
  • Procarbazine hydrochloride

Superlist Names

  • Benzamide, N-(1-methylethyl)-4-((2-methylhydrazino)methyl)-, monohydrochloride
  • Procarbazine hydrochloride

Registry Numbers

CAS Registry Number

  • 366-70-1

FDA UNII

  • XH0NPH5ZX8

Related Registry Number

  • 671-16-9 (Parent)

System Generated Number

  • 0000366701

Molecular Formulas

Molecular Formulas

  • C12-H19-N3-O.Cl-H
  • C12-H9-N3-O.Cl-H

Molecular Formula Fragments

  • C12-H19-N3-O
  • C12-H9-N3-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

InChI=1S/C12H19N3O.ClH/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3;/h4-7,9,13-14H,8H2,1-3H3,(H,15,16);1H

InChIKey

DERJYEZSLHIUKF-UHFFFAOYSA-N

Smiles

Cl.CNNCc1ccc(cc1)C(=O)NC(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 699mg/kg (699mg/kg)   Archives of Toxicology. Vol. 41, Pg. 287, 1979.
mouse LD50 intravenous 540mg/kg (540mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 467, 1973.
mouse LD50 oral 560mg/kg (560mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 467, 1973.
mouse LD50 subcutaneous 710mg/kg (710mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 467, 1973.
mouse LD50 unreported 1320mg/kg (1320mg/kg) IMMUNOLOGICAL INCLUDING ALLERGIC: DECREASED IMMUNE RESPONSE

BLOOD: THROMBOCYTOPENIA

BLOOD: LEUKOPENIA
Environmental Science Research. Vol. 24, Pg. 977, 1981.
rabbit LD50 unreported 145mg/kg (145mg/kg) BLOOD: THROMBOCYTOPENIA

IMMUNOLOGICAL INCLUDING ALLERGIC: DECREASED IMMUNE RESPONSE

BLOOD: LEUKOPENIA
Environmental Science Research. Vol. 24, Pg. 977, 1981.
rat LD50 intravenous 350mg/kg (350mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1467, 1970.
rat LD50 oral 570mg/kg (570mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 355, 1972.
rat LD50 subcutaneous 490mg/kg (490mg/kg)   Drugs in Japan Vol. 6, Pg. 720, 1982.
rat LD50 unreported 785mg/kg (785mg/kg) BLOOD: LEUKOPENIA

BLOOD: THROMBOCYTOPENIA

IMMUNOLOGICAL INCLUDING ALLERGIC: DECREASED IMMUNE RESPONSE
Environmental Science Research. Vol. 24, Pg. 977, 1981.