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Substance Name: Quazepam [USAN:USP:INN:BAN]
RN: 36735-22-5
UNII: JF8V0828ZI
InChIKey: IKMPWMZBZSAONZ-UHFFFAOYSA-N

Molecular Formula

  • C17-H11-Cl-F4-N2-S

Molecular Weight

  • 386.7989
 

Classification Codes

Classification Codes

  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • Hypnotics and Sedatives
  • Reproductive Effect
  • Sedative-Hypnotic

Superlist Classification Code

  • DEA Schedule IV
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Names and Synonyms

Name of Substance

  • Quazepam
  • Quazepam [USAN:USP:INN:BAN]

Synonyms

  • 5-24-04-00356 (Beilstein Handbook Reference)
  • 7-Chloro-5-(o-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)-2H-1,4-benzodiazepine-2-thione
  • BRN 0901084
  • Doral
  • Doral [Sedative]
  • Dormalin
  • EINECS 253-179-4
  • NSC 309702
  • Oniria
  • Prosedar
  • Quazapam
  • Quazepam
  • Quazepamum
  • Quazepamum [INN-Latin]
  • Quazium
  • Sch 16134
  • Selepam
  • UNII-JF8V0828ZI

Systematic Names

  • 2H-1,4-Benzodiazepine-2-thione, 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)-
  • 7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)-2H-1,4-benzodiazepine-2-thione
  • Quazepam

Superlist Names

  • DEA No. 2881
  • Quazepam

Registry Numbers

CAS Registry Number

  • 36735-22-5

FDA UNII

  • JF8V0828ZI

System Generated Number

  • 0036735225

Structure Descriptors

InChI

InChI=1S/C17H11ClF4N2S/c18-10-5-6-14-12(7-10)16(11-3-1-2-4-13(11)19)23-8-15(25)24(14)9-17(20,21)22/h1-7H,8-9H2

InChIKey

IKMPWMZBZSAONZ-UHFFFAOYSA-N

Smiles

Fc1ccccc1C2=NCC(=S)N(CC(F)(F)F)c3ccc(Cl)cc23

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD oral > 1gm/kg (1000mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: ANALGESIA
Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 1456, 1982.
dog LD oral > 1gm/kg (1000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 37, Pg. 906, 1987.
mouse LD50 intraperitoneal 845mg/kg (845mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Arzneimittel-Forschung. Drug Research. Vol. 37, Pg. 906, 1987.
mouse LDLo oral 5gm/kg (5000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 1456, 1982.
rat LD50 intraperitoneal 2749mg/kg (2749mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Arzneimittel-Forschung. Drug Research. Vol. 37, Pg. 906, 1987.
rat LD50 oral > 5gm/kg (5000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 37, Pg. 906, 1987.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 137.5-139 deg C   EXP
log P (octanol-water) 4.03 (none)   EXP
Water Solubility 1.340 mg/L 25 EST
Vapor Pressure 9.17E-09 mm Hg 25 EST
Henry's Law Constant 1.28E-06 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 5.60E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.