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Substance Name: Lurasidone hydrochloride [USAN]
RN: 367514-88-3
UNII: O0P4I5851I
InChIKey: NEKCRUIRPWNMLK-SCIYSFAVSA-N

Note

  • A thiazole derivative and atypical ANTIPSYCHOTIC AGENT that functions as a DOPAMINE D2 RECEPTOR ANTAGONIST; SEROTONIN 5-HT2 RECEPTOR ANTAGONIST, serotonin 5-HT7 receptor antagonist, and antagonist of the adrenergic α2A and α2C receptors, as well as a partial SEROTONIN 5-HT1A RECEPTOR AGONIST. It is used in the treatment of SCHIZOPHRENIA and BIPOLAR DISORDER.

Molecular Formula

  • C28-H36-N4-O2-S.Cl-H

Molecular Weight

  • 529.1453
 

Classification Codes

  • Adrenergic Agents
  • Adrenergic alpha-2 Receptor Antagonists
  • Adrenergic alpha-Antagonists
  • Adrenergic Antagonists
  • Antipsychotic Agents
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Dopamine Agents
  • Dopamine Antagonists
  • Dopamine D2 Receptor Antagonists
  • Neurotransmitter Agents
  • Psychotropic Drugs
  • Serotonin 5-HT2 Receptor Antagonists
  • Serotonin Agents
  • Serotonin Antagonists
  • Tranquilizing Agents
  • Treatment of Schizophrenia (High-Affinity Agonist of Serotonin 5-HT1A, 5-HT2, and 5-HT7 Receptors as Well as Dopamine D2 Receptors)
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Names and Synonyms

Name of Substance

  • Lurasidone hydrochloride [USAN]

MeSH Heading

  • Lurasidone Hydrochloride

Synonyms

  • Latuda
  • Lurasidone HCl
  • Lurasidone hydrochloride
  • SM 13496
  • SM-13496
  • UNII-O0P4I5851I

Systematic Name

  • 4,7-Methano-1H-isoindole-1,3(2H)-dione, 2-(((1R,2R)-2-((4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)methyl)cyclohexyl)methyl)hexahydro-, monohydrochloride, (3aR,4S,7R,7aS)-

Registry Numbers

CAS Registry Number

  • 367514-88-3

FDA UNII

  • O0P4I5851I

Other Registry Number

  • 441351-20-8

System Generated Number

  • 0367514883

Molecular Formulas

Molecular Formula

  • C28-H36-N4-O2-S.Cl-H

Molecular Formula Fragments

  • C28-H36-N4-O2-S
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

InChI=1S/C28H36N4O2S.ClH/c33-27-24-18-9-10-19(15-18)25(24)28(34)32(27)17-21-6-2-1-5-20(21)16-30-11-13-31(14-12-30)26-22-7-3-4-8-23(22)35-29-26;/h3-4,7-8,18-21,24-25H,1-2,5-6,9-17H2;1H/t18-,19+,20-,21-,24+,25-;/m0./s1

InChIKey

NEKCRUIRPWNMLK-SCIYSFAVSA-N

Smiles

Cl.O=C1[C@@H]2[C@H]3CC[C@H](C3)[C@@H]2C(=O)N1C[C@@H]4CCCC[C@H]4CN5CCN(CC5)c6nsc7ccccc67