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Substance Name: Ribavirin [USAN:USP:INN:BAN]
RN: 36791-04-5
UNII: 49717AWG6K
InChIKey: IWUCXVSUMQZMFG-AFCXAGJDSA-N
Note
- A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses.
Molecular Formula
- C8-H12-N4-O5
Molecular Weight
- 244.206
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- Toxicity
- Physical Properties
Classification Codes
- Anti-Infective Agents
- Antimetabolites
- Antiviral
- Antiviral Agents
- Drug / Therapeutic Agent
- Mutation Data
- Noxae
- Reproductive Effect
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Names and Synonyms
Name of Substance
- Ribavirin
- Ribavirin [USAN:USP:INN:BAN]
MeSH Heading
- Ribavirin
Synonyms
- 1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide
- 1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide
- BRN 0892462
- Copegus
- DRG-0028
- HSDB 6513
- ICN-1229
- NSC 163039
- Rebetol
- Ribamide
- Ribamidil
- Ribamidyl
- Ribasphere
- Ribavirin
- Ribavirin Capsules
- Ribavirina
- Ribavirina [INN-Spanish]
- Ribavirine
- Ribavirine [INN-French]
- Ribavirinum
- Ribavirinum [INN-Latin]
- RTC
- RTCA
- SCH 18908
- Tribavirin
- UNII-49717AWG6K
- Varazid
- Vilona
- Viramid
- Virazole
Systematic Names
- 1,2,4-Triazole-3-carboxamide, 1-beta-D-ribofuranosyl-
- 1H-1,2,4-Triazole-3-carboxamide, 1-beta-D-ribofuranosyl-
Superlist Name
- Ribavirin
Mixture Name
- Rebetron
Registry Numbers
CAS Registry Number
- 36791-04-5
FDA UNII
- 49717AWG6K
Other Registry Numbers
- 437710-49-1
- 66510-90-5
System Generated Number
- 0036791045
Structure Descriptors
InChI
1S/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16)/t3-,4-,5-,8-/m1/s1InChIKey
IWUCXVSUMQZMFG-AFCXAGJDSA-NSmiles
n1([C@@H]2O[C@H](CO)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LDLo | unreported | 1500mg/kg (1500mg/kg) | KIDNEY, URETER, AND BLADDER: OTHER CHANGES GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BLOOD: HEMORRHAGE | Pharmaceutical Chemistry Journal Vol. 18, Pg. 667, 1984. |
| mouse | LD50 | intraperitoneal | 1300mg/kg (1300mg/kg) | Journal of Medicinal Chemistry. Vol. 15, Pg. 1150, 1972. | |
| mouse | LDLo | oral | 4gm/kg (4000mg/kg) | Pharmaceutical Chemistry Journal Vol. 18, Pg. 667, 1984. | |
| rat | LD50 | oral | 2700mg/kg (2700mg/kg) | Pharmaceutical Chemistry Journal Vol. 18, Pg. 667, 1984. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| log P (octanol-water) | -1.85E+00 | (none) | EXP | |
| Water Solubility | 4.74E+04 | mg/L | 25 | EST |
| Vapor Pressure | 5.10E-13 | mm Hg | 25 | EST |
| Henry's Law Constant | 9.96E-22 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 4.05E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.