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Substance Name: Meclofenoxate hydrochloride [JAN]
RN: 3685-84-5
UNII: 5BK3070BDY
InChIKey: FIVHOHCAXWQPGC-UHFFFAOYSA-N

Note

  • An ester of DIMETHYLAMINOETHANOL and para-chlorophenoxyacetic acid.

Molecular Formula

  • C12-H16-Cl-N-O3.Cl-H

Molecular Weight

  • 294.1763
 

Classification Codes

  • Central Nervous System Agents
  • Drug / Therapeutic Agent
  • Neuroprotective Agents
  • Nootropic Agents
  • Protective Agents
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Names and Synonyms

Name of Substance

  • Meclofenoxate hydrochloride
  • Meclofenoxate hydrochloride [JAN]

MeSH Heading

  • Meclofenoxate

Synonyms

  • (p-Chlorophenoxy)acetic acid 2-(dimethylamino)ethyl ester hydrochloride
  • 235 Anp hydrochloride
  • Acefen
  • Amipolen
  • Atsefen
  • Brenal
  • Cellative
  • Centrofenoxin
  • Centrophenoxine
  • Centrophenoxine (VAN)
  • Centrophenoxine hydrochloride
  • Cerutil
  • Chlorowodorki centrofenoksyna
  • Chlorowodorki centrofenoksyna [Polish]
  • Dimethylaminoethyl 4-chlorophenoxyacetate hydrochloride
  • Dimethylaminoethyl ester of p-chlorophenoxyacetic acid hydrochloride
  • Dimethylaminoethyl p-chlorophenoxyacetate hydrochloride
  • EINECS 222-975-3
  • Helfergin
  • Lucidril
  • Lutiaron
  • Marucotol
  • Meclofenoxate HCl
  • Meclofenoxate hydrochloride
  • Meclophenoxate hydrochloride
  • Methoxynal
  • NSC 113619
  • NSC 4268
  • p-Chlorphenoxyessigsaeure-beta-dimethylaminoaethylesters
  • p-Chlorphenoxyessigsaeure-beta-dimethylaminoaethylesters [German]
  • Proserout
  • UNII-5BK3070BDY

Systematic Names

  • Acetic acid, (4-chlorophenoxy)-, 2-(dimethylamino)ethyl ester, hydrochloride (9CI)
  • Acetic acid, (p-chlorophenoxy)-, 2-dimethylaminoethyl ester, hydrochloride
  • Meclofenoxate hydrochloride

Registry Numbers

CAS Registry Number

  • 3685-84-5

FDA UNII

  • 5BK3070BDY

Other Registry Number

  • 1334-20-9

System Generated Number

  • 0003685845

Molecular Formulas

Molecular Formula

  • C12-H16-Cl-N-O3.Cl-H

Molecular Formula Fragments

  • C12-H16-Cl-N-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C12H16ClNO3.ClH/c1-14(2)7-8-16-12(15)9-17-11-5-3-10(13)4-6-11;/h3-6H,7-9H2,1-2H3;1H

InChIKey

FIVHOHCAXWQPGC-UHFFFAOYSA-N

Smiles

c1(ccc(Cl)cc1)OCC(OCCN(C)C)=O.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 660mg/kg (660mg/kg)   Drugs in Japan Vol. 6, Pg. 814, 1982.
mouse LD50 intravenous 330mg/kg (330mg/kg)   French Medicament Patent Document. Vol. #398M,
mouse LD50 oral 1750mg/kg (1750mg/kg)   Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 153, Pg. 1914, 1959.
mouse LD50 subcutaneous 1560mg/kg (1560mg/kg)   Drugs in Japan Vol. 6, Pg. 814, 1982.
rabbit LDLo intravenous 150mg/kg (150mg/kg)   Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 153, Pg. 1914, 1959.
rat LD50 oral 865mg/kg (865mg/kg)   Khimiya v Sel'skom Khozyaistve. Chemistry in Agriculture. Vol. 16(2), Pg. 59, 1978.