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Substance Name: Codeine N-oxide
RN: 3688-65-1
UNII: Z32OFX7V17
InChIKey: BDLSDHWCOJPHIE-KFUGMXNISA-N

Molecular Formula

  • C18-H21-N-O4

Molecular Weight

  • 315.367
 

Classification Codes

Classification Code

  • Drug / Therapeutic Agent

Superlist Classification Code

  • DEA Schedule I
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Names and Synonyms

Name of Substance

  • Codeine N-oxide

Synonyms

  • Codeigene
  • Codeine N-oxide
  • EINECS 222-988-4
  • Genocodein
  • Genocodeine
  • Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, 17-oxide, (5-alpha,6-alpha)-
  • UNII-Z32OFX7V17

Systematic Names

  • Codeine N-oxide
  • Morphinan-6-alpha-ol, 7,8-didehydro-4,5-alpha-epoxy-3-methoxy-17-methyl-, 17-oxide

Superlist Names

  • Codeine-N-oxide
  • DEA No. 9053

Registry Numbers

CAS Registry Number

  • 3688-65-1

FDA UNII

  • Z32OFX7V17

System Generated Number

  • 0003688651

Structure Descriptors

InChI

1S/C18H21NO4/c1-19(21)8-7-18-11-4-5-13(20)17(18)23-16-14(22-2)6-3-10(15(16)18)9-12(11)19/h3-6,11-13,17,20H,7-9H2,1-2H3/t11-,12+,13-,17-,18-,19-/m0/s1

InChIKey

BDLSDHWCOJPHIE-KFUGMXNISA-N

Smiles

c12[C@]34[C@@H]5[C@H]([N@@+](C)([O-])CC4)Cc2ccc(c1O[C@H]3[C@@H](O)C=C5)OC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 767mg/kg (767mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 54, Pg. 688, 1958.
rat LD50 intravenous 800mg/kg (800mg/kg)   Yakugaku Zasshi. Journal of Pharmacy. Vol. 80, Pg. 1501, 1960.
rat LD50 oral 1600mg/kg (1600mg/kg)   Yakugaku Zasshi. Journal of Pharmacy. Vol. 80, Pg. 1501, 1960.
rat LD50 subcutaneous > 1500mg/kg (1500mg/kg)   Yakugaku Zasshi. Journal of Pharmacy. Vol. 80, Pg. 1501, 1960.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 231.5 deg C   EXP
log P (octanol-water) 0.730 (none)   EST
Atmospheric OH Rate Constant 1.77E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.