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Substance Name: Nicocodine [INN:BAN:DCF]
RN: 3688-66-2
UNII: DYX391P13E
InChIKey: RYBGRHAWFUVMST-MJFIPZRTSA-N

Molecular Formula

  • C24-H24-N2-O4

Molecular Weight

  • 404.4636
 

Classification Codes

Classification Code

  • Antitussive

Superlist Classification Code

  • DEA Schedule I
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Names and Synonyms

Name of Substance

  • Nicocodine
  • Nicocodine [INN:BAN:DCF]

Synonyms

  • 4,5-Epoxy-3-methoxy-9a-methyl-7-morphinen-6alpha-yl nicotinat
  • 4,5alpha-Epoxy-3-methoxy-9alpha-methyl-7-morphinen-6alpha-yl nicotinat
  • BRN 0633524
  • Codeine, nicotinate (ester)
  • EINECS 222-990-5
  • Lyopect
  • Nicocodina
  • Nicocodina [INN-Spanish]
  • Nicocodine
  • Nicocodinum
  • Nicocodinum [INN-Latin]
  • Nicotinic acid, 7,8-didehydro-4,5-alpha-epoxy-3-methoxy-17-methylmorphinan-6-alpha-yl ester
  • Nicotinic acid, ester with codeine
  • RC 146
  • UNII-DYX391P13E

Systematic Names

  • (5alpha,6alpha)-7,8-Didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-ol, 3-pyridinecarboxylate (ester)
  • 6-Nicotinoylcodeine
  • Morphinan-6-alpha-ol, 7,8-didehydro-4,5-alpha-epoxy-3-methoxy-17-methyl-, nicotinate (ester)
  • Nicocodine

Superlist Names

  • DEA No. 9309
  • Nicocodeine

Registry Numbers

CAS Registry Number

  • 3688-66-2

FDA UNII

  • DYX391P13E

Related Registry Number

  • 58263-01-7 (hydrochloride)

System Generated Number

  • 0003688662

Structure Descriptors

InChI

1S/C24H24N2O4/c1-26-11-9-24-16-6-8-19(29-23(27)15-4-3-10-25-13-15)22(24)30-21-18(28-2)7-5-14(20(21)24)12-17(16)26/h3-8,10,13,16-17,19,22H,9,11-12H2,1-2H3/t16-,17+,19-,22-,24-/m0/s1

InChIKey

RYBGRHAWFUVMST-MJFIPZRTSA-N

Smiles

COc1ccc2C[C@@H]3[C@@H]4C=C[C@H](OC(=O)c5cccnc5)[C@@H]6Oc1c2[C@]46CCN3C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 48mg/kg (48mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 143, Pg. 466, 1963.
mouse LD50 oral 280mg/kg (280mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 143, Pg. 466, 1963.
rat LD50 intraperitoneal 37mg/kg (37mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 143, Pg. 466, 1963.
rat LD50 oral 840mg/kg (840mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 143, Pg. 466, 1963.