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Substance Name: Aminopropylon
RN: 3690-04-8
UNII: JB5F72V65T
InChIKey: UQNCVOXEVRELFR-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C16-H22-N4-O2

Molecular Weight

  • 302.3758
 
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Names and Synonyms

Name of Substance

  • Aminopropylon

Synonyms

  • 4-(2-(Dimethylamino)propionamido)antipyrine
  • 4-25-00-03595 (Beilstein Handbook Reference)
  • Aminopropylon
  • Aminopropylone
  • Amipylo
  • BRN 0038137
  • EINECS 222-999-4
  • N-Antipyrinyl-2-(dimethylamino)propionamide
  • Propanamide, N-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-2-(dimethylamino)-
  • UNII-JB5F72V65T

Systematic Names

  • N-(2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-2-(dimethylamino)propionamide
  • Propionamide, N-antipyrinyl-2-(dimethylamino)-

Registry Numbers

CAS Registry Number

  • 3690-04-8

FDA UNII

  • JB5F72V65T

Other Registry Numbers

  • 62951-82-0
  • 68712-82-3

System Generated Number

  • 0003690048

Structure Descriptors

InChI

1S/C16H22N4O2/c1-11-14(17-15(21)12(2)18(3)4)16(22)20(19(11)5)13-9-7-6-8-10-13/h6-10,12H,1-5H3,(H,17,21)

InChIKey

UQNCVOXEVRELFR-UHFFFAOYSA-N

Smiles

Cc1c(c(=O)n(n1C)c2ccccc2)NC(=O)C(C)N(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular 2120mg/kg (2120mg/kg) BEHAVIORAL: ANALGESIA Oyo Yakuri. Pharmacometrics. Vol. 13, Pg. 109, 1977.
mouse LD50 intraperitoneal 820mg/kg (820mg/kg) BEHAVIORAL: ANALGESIA Oyo Yakuri. Pharmacometrics. Vol. 13, Pg. 109, 1977.
mouse LD50 intravenous 701mg/kg (701mg/kg)   Polish Medical Sciences and History Bulletin. Vol. 17(4), Pg. 323, 1974.
mouse LD50 oral 2950mg/kg (2950mg/kg) BEHAVIORAL: ANALGESIA Oyo Yakuri. Pharmacometrics. Vol. 13, Pg. 109, 1977.
mouse LD50 oral > 3gm/kg (3000mg/kg)   Polish Medical Sciences and History Bulletin. Vol. 17(4), Pg. 323, 1974.
mouse LD50 subcutaneous 1970mg/kg (1970mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Scientia Pharmaceutica. Vol. 37, Pg. 185, 1969.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 181 deg C   EXP
log P (octanol-water) -0.05 (none)   EXP
Water Solubility 643 mg/L 25 EST
Vapor Pressure 3.92E-10 mm Hg 25 EST
Henry's Law Constant 1.93E-13 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.16E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.