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Substance Name: Prolinomethyltetracycline
RN: 37106-99-3
InChIKey: NSLVHESRHHEPEW-CRRREAHRSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C28-H33-N3-O10

Molecular Weight

  • 571.5797
 
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Names and Synonyms

Name of Substance

  • Prolinomethyltetracycline

Synonyms

  • PM-TC
  • Prolinomethyltetracycline

Systematic Name

  • L-Proline, 1-((((4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenyl)carbonyl)amino)methyl)-, (4S-(4-alpha,4a-alpha,5a-alpha,6-beta,12a-alpha))-

Registry Numbers

CAS Registry Number

  • 37106-99-3

System Generated Number

  • 0037106993

Structure Descriptors

InChI

1S/C28H33N3O10/c1-27(40)12-6-4-8-16(32)17(12)21(33)18-13(27)10-14-20(30(2)3)22(34)19(24(36)28(14,41)23(18)35)25(37)29-11-31-9-5-7-15(31)26(38)39/h4,6,8,13-15,20,32,34-35,40-41H,5,7,9-11H2,1-3H3,(H,29,37)(H,38,39)/t13-,14-,15+,20-,27-,28-/m1/s1

InChIKey

NSLVHESRHHEPEW-CRRREAHRSA-N

Smiles

CN(C)[C@@H]1[C@H]2C[C@@H]3C(=C(O)[C@@]2(O)C(=O)C(=C1O)C(=O)NCN4CCC[C@H]4C(=O)O)C(=O)c5c(O)cccc5[C@@]3(C)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular 283mg/kg (283mg/kg)   Japanese Journal of Antibiotics. Vol. 24, Pg. 156, 1971.
mouse LD50 intraperitoneal 353mg/kg (353mg/kg) BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA
Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 51, 1972.
mouse LD50 intravenous 85100ug/kg (85.1mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 51, 1972.
mouse LD50 oral > 3150mg/kg (3150mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 51, 1972.
mouse LD50 subcutaneous 1465mg/kg (1465mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: ATAXIA
Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 51, 1972.
rat LD50 intramuscular 788mg/kg (788mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 51, 1972.
rat LD50 intraperitoneal 115mg/kg (115mg/kg)   Japanese Journal of Antibiotics. Vol. 25, Pg. 95, 1972.
rat LD50 intravenous 144mg/kg (144mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 51, 1972.
rat LD50 oral > 3150mg/kg (3150mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 51, 1972.
rat LD50 subcutaneous 1733mg/kg (1733mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA

BEHAVIORAL: EXCITEMENT
Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 51, 1972.