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Substance Name: Tramazoline hydrochloride [USAN:JAN]
RN: 3715-90-0
UNII: 4DG710Q678
InChIKey: RZOXEODOFNEZRS-UHFFFAOYSA-N

Classification Codes

  • Antagonist (to Histamine H2 Receptors)
  • Drug / Therapeutic Agent

Molecular Formula

  • C13-H17-N3.Cl-H

Molecular Weight

  • 251.7592
 
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Names and Synonyms

Name of Substance

  • Tramazoline hydrochloride
  • Tramazoline hydrochloride [USAN:JAN]

Synonyms

  • 1H-Imidazol-2-amine, 4,5-dihydro-N-(5,6,7,8-tetrahydro-1-naphthalenyl)-, monohydrochloride
  • 2'-(5,6,7,8-Tetrahydro-1-naphthylamino)imidazoline hydrochloride
  • 2-((5,6,7,8-Tetrahydro-1-naphthyl)amino)-2-imidazoline monohydrochloride
  • Biciron
  • EINECS 223-064-3
  • Ellatun
  • KB 227
  • Rhinospray
  • Rinogutt
  • Tetrahydronaphthylaminoimidazoline hydrochloride
  • Towk
  • Tramazoline HCl
  • Tramazoline hydrochloride
  • UNII-4DG710Q678

Systematic Names

  • 1H-Imidazol-2-amine, 4,5-dihydro-N-(5,6,7,8-tetrahydro-1-naphthalenyl)-, monohydrochloride
  • 2-Imidazoline, 2-((5,6,7,8-tetrahydro-1-naphthyl)amino)-, monohydrochloride
  • Tramazoline hydrochloride

Registry Numbers

CAS Registry Number

  • 3715-90-0

FDA UNII

  • 4DG710Q678

Related Registry Number

  • 1082-57-1 (Parent)

System Generated Number

  • 0003715900

Molecular Formulas

Molecular Formula

  • C13-H17-N3.Cl-H

Molecular Formula Fragments

  • C13-H17-N3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C13H17N3.ClH/c1-2-6-11-10(4-1)5-3-7-12(11)16-13-14-8-9-15-13;/h3,5,7H,1-2,4,6,8-9H2,(H2,14,15,16);1H

InChIKey

RZOXEODOFNEZRS-UHFFFAOYSA-N

Smiles

c1cc2c(c(c1)NC3=NCCN3)CCCC2.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 57mg/kg (57mg/kg)   Drugs in Japan Vol. -, Pg. 859, 1995.
mouse LD50 intravenous 11600ug/kg (11.6mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1760, 1980.
mouse LD50 oral 130mg/kg (130mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1760, 1980.
mouse LD50 subcutaneous 77mg/kg (77mg/kg)   Drugs in Japan Vol. -, Pg. 859, 1995.
rat LD50 oral 190mg/kg (190mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1760, 1980.