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Substance Name: Flavoxate hydrochloride [USAN:USP:JAN]
RN: 3717-88-2
UNII: 9C05J6089W
InChIKey: XOEVKNFZUQEERE-UHFFFAOYSA-N

Note

  • A drug that has been used in various urinary syndromes and as an antispasmodic. Its therapeutic usefulness and its mechanism of action are not clear. It may have local anesthetic activity and direct relaxing effects on smooth muscle as well as some activity as a muscarinic antagonist.

Molecular Formula

  • C24-H25-N-O4.Cl-H

Molecular Weight

  • 427.9254
 

Classification Codes

  • Drug / Therapeutic Agent
  • Mutation Data
  • Relaxant (Smooth Muscle)
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Flavoxate hydrochloride [USAN:USP:JAN]

Synonyms

  • 1-Piperidineethanol, 3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylate, hydrochloride
  • 2-Piperidinoethyl 3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylate hydrochloride
  • Bladderon
  • CCRIS 1950
  • DW 61 (flavoxate)
  • DW-61
  • EINECS 223-066-4
  • Flavoxate HCl
  • Flavoxate hydrochloride
  • Genurin
  • NSC 114649
  • NSC-114649
  • Peflate
  • Piperidinoethyl-3-methylflavone-8-carboxylate hydrochloride
  • REC 7-0040
  • Rec 7/0040
  • Spasmal
  • Spasuret
  • UNII-9C05J6089W
  • Urispadol
  • Urispas
  • Verrispasmin amp.

Systematic Names

  • 4H-1-Benzopyran-8-carboxylic acid, 3-methyl-4-oxo-2-phenyl-, 2-(1-piperidinyl)ethyl ester, hydrochloride
  • 4H-1-Benzopyran-8-carboxylic acid, 3-methyl-4-oxo-2-phenyl-, 2-piperidinoethyl ester, hydrochloride
  • Flavoxate hydrochloride

Registry Numbers

CAS Registry Number

  • 3717-88-2

FDA UNII

  • 9C05J6089W

System Generated Number

  • 0003717882

Molecular Formulas

Molecular Formula

  • C24-H25-N-O4.Cl-H

Molecular Formula Fragments

  • C24-H25-N-O4
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C24H25NO4.ClH/c1-17-21(26)19-11-8-12-20(23(19)29-22(17)18-9-4-2-5-10-18)24(27)28-16-15-25-13-6-3-7-14-25;/h2,4-5,8-12H,3,6-7,13-16H2,1H3;1H

InChIKey

XOEVKNFZUQEERE-UHFFFAOYSA-N

Smiles

Cc1c(=O)c2cccc(c2oc1c3ccccc3)C(=O)OCCN4CCCCC4.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 350mg/kg (350mg/kg) BEHAVIORAL: ANALGESIA

AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)"

PERIPHERAL NERVE AND SENSATION: LOCAL ANESTHETIC
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 131, Pg. 187, 1961.
mouse LD50 intravenous 28mg/kg (28mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 232, 1979.
mouse LD50 oral 740mg/kg (740mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Journal of Pharmacology and Experimental Therapeutics. Vol. 130, Pg. 356, 1960.
mouse LD50 subcutaneous 610mg/kg (610mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 232, 1979.
rabbit LD50 intravenous 25mg/kg (25mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 3, Pg. 1214, 1975.
rabbit LD50 oral > 6gm/kg (6000mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 3, Pg. 1214, 1975.
rat LD50 intraperitoneal 170mg/kg (170mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15, Pg. 5271, 1987.
rat LD50 intravenous 25mg/kg (25mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 232, 1979.
rat LD50 oral 1040mg/kg (1040mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15, Pg. 5271, 1987.
rat LD50 subcutaneous 1010mg/kg (1010mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 232, 1979.