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Substance Name: Mellitin
RN: 37231-28-0
InChIKey: VDXZNPDIRNWWCW-UHFFFAOYSA-N

Note

  • Basic polypeptide from the venom of the honey bee (Apis mellifera). It contains 26 amino acids, has cytolytic properties, causes contracture of muscle, releases histamine, and disrupts surface tension, probably due to lysis of cell and mitochondrial membranes.

Molecular Formula

  • C131-H229-N39-O31

Molecular Weight

  • 2846.4921
 

Classification Codes

  • Drug / Therapeutic Agent
  • Mutation Data
  • Natural Product
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Names and Synonyms

Results Name

  • Mellitin

Name of Substance

  • Melitten

Synonyms

  • EINECS 253-417-7
  • Forapin
  • Forapine
  • Melittin I
  • Melittin-T
  • Mellitin

Systematic Names

  • L-Glutamamide, glycyl-L-isoleucylglycyl-L-alanyl-L-valyl-L-leucyl-L-lysyl-L-valyl-L-leucyl-L-threonyl-L-threonylglycyl-L-leucyl-L-prolyl-L-alanyl-L-leucyl-L-isoleucyl-L-seryl-L-tryptophyl-L-isoleucyl-L-lysyl-L-arginyl-L-lysyl-L-arginyl-L-glutaminyl-
  • Melittin

Registry Numbers

CAS Registry Number

  • 37231-28-0

Other Registry Number

  • 11030-50-5

System Generated Number

  • 0037231280

Structure Descriptors

InChI

1S/C131H229N39O31/c1-23-71(16)102(163-97(176)60-135)122(194)146-62-98(177)148-74(19)109(181)164-100(69(12)13)124(196)160-88(55-65(4)5)116(188)155-84(41-30-33-51-134)115(187)165-101(70(14)15)125(197)161-90(57-67(8)9)118(190)168-106(77(22)173)128(200)169-105(76(21)172)123(195)147-63-99(178)150-92(58-68(10)11)129(201)170-54-36-44-94(170)121(193)149-75(20)108(180)158-89(56-66(6)7)117(189)166-104(73(18)25-3)127(199)162-93(64-171)120(192)159-91(59-78-61-145-80-38-27-26-37-79(78)80)119(191)167-103(72(17)24-2)126(198)157-83(40-29-32-50-133)111(183)154-85(42-34-52-143-130(139)140)112(184)152-82(39-28-31-49-132)110(182)153-86(43-35-53-144-131(141)142)113(185)156-87(46-48-96(137)175)114(186)151-81(107(138)179)45-47-95(136)174/h26-27,37-38,61,65-77,81-94,100-106,145,171-173H,23-25,28-36,39-60,62-64,132-135H2,1-22H3,(H2,136,174)(H2,137,175)(H2,138,179)(H,146,194)(H,147,195)(H,148,177)(H,149,193)(H,150,178)(H,151,186)(H,152,184)(H,153,182)(H,154,183)(H,155,188)(H,156,185)(H,157,198)(H,158,180)(H,159,192)(H,160,196)(H,161,197)(H,162,199)(H,163,176)(H,164,181)(H,165,187)(H,166,189)(H,167,191)(H,168,190)(H,169,200)(H4,139,140,143)(H4,141,142,144)

InChIKey

VDXZNPDIRNWWCW-UHFFFAOYSA-N

Smiles

[H]/N=C(\N)/NCCCC(C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)N)C(=O)N)NC(=O)C(CCCCN)NC(=O)C(CCCN/C(=N/[H])/N)NC(=O)C(CCCCN)NC(=O)C(C(C)CC)NC(=O)C(Cc1c[nH]c2c1cccc2)NC(=O)C(CO)NC(=O)C(C(C)CC)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C3CCCN3C(=O)C(CC(C)C)NC(=O)CNC(=O)C(C(C)O)NC(=O)C(C(C)O)NC(=O)C(CC(C)C)NC(=O)C(C(C)C)NC(=O)C(CCCCN)NC(=O)C(CC(C)C)NC(=O)C(C(C)C)NC(=O)C(C)NC(=O)CNC(=O)C(C(C)CC)NC(=O)CN

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intraarterial 400ug/kg (0.4mg/kg)   Toxicon. Vol. 13, Pg. 277, 1975.
cat LDLo intravenous 6mg/kg (6mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION
Toxicon. Vol. 13, Pg. 277, 1975.
mouse LD50 intracrebral 860ug/kg (0.86mg/kg)   Toxicon. Vol. 22, Pg. 308, 1984.
mouse LD50 intraperitoneal 5mg/kg (5mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 1921, 1972.
mouse LD50 intravenous 3500ug/kg (3.5mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: EXCITEMENT
"Venomous Animals and Their Venoms," Buecherl, W., and E.E. Buckley, eds., 3 vols., New York, Academic Press, Inc., 1968-71Vol. 3, Pg. 61, 1971.
mouse LD50 parenteral 2500ug/kg (2.5mg/kg)   Toxicon. Vol. 12, Pg. 139, 1974.