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Substance Name: Serine proteinase
RN: 37259-58-8

Note

  • Peptide hydrolases that contain at the active site a SERINE residue involved in catalysis.

Molecular Formula

  • Unspecified
 

Classification Codes

  • Drug / Therapeutic Agent
  • Natural Product
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Links to Resources

Names and Synonyms

Results Name

  • Serine proteinase

MeSH Heading

  • Serine Proteases

Synonyms

  • alpha-Fibrinogenase
  • Caldolase
  • Cerastobin
  • Clp proteinase
  • EINECS 253-431-3
  • Maxacal
  • Porzyme 6
  • Proteinase T
  • Serine endopeptidase
  • Serine esterase
  • Serine peptidase
  • Serine protease
  • Serine proteinase
  • Seryl protease
  • Tryase

Systematic Name

  • Proteinase, serine

Registry Numbers

CAS Registry Number

  • 37259-58-8

System Generated Number

  • 0037259588

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 64100ug/kg (64.1mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM LARGE INTESTINE

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE
Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 2731, 1974.
mouse LD50 oral 15900mg/kg (15900mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 2731, 1974.
mouse LD50 subcutaneous 110mg/kg (110mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 2731, 1974.
rat LD50 intraperitoneal 62900ug/kg (62.9mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM LARGE INTESTINE
Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 2731, 1974.
rat LD50 oral 14400mg/kg (14400mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 2731, 1974.
rat LD50 subcutaneous 82900ug/kg (82.9mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 2731, 1974.