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Substance Name: Colestipol hydrochloride [USAN:USP]
RN: 37296-80-3
UNII: X7D10K905G
InChIKey: GACQNVJDWUAPFY-UHFFFAOYSA-N

Note

  • Highly crosslinked and insoluble basic anion exchange resin used as anticholesteremic. It may also may reduce triglyceride levels.

Molecular Weight

  • 225.7656
 

Classification Codes

  • Antihyperlipidemic
  • Drug / Therapeutic Agent

Names and Synonyms

Name of Substance

  • Colestipol hydrochloride [USAN:USP]

Synonyms

  • Cholestabyl
  • Colestid
  • Colestipol HCl
  • Colestipol hydrochloride
  • Copolymer of diethylenetriamine and 1-chloro-2,3-epoxypropane, hydrochloride (with approximately 1 out of 5 amine nitrogens protonated)
  • Flavored Colestid
  • Lestid
  • U-26597A
  • UNII-X7D10K905G

Systematic Name

  • Colestipol hydrochloride

Registry Numbers

CAS Registry Number

  • 37296-80-3

FDA UNII

  • X7D10K905G

System Generated Number

  • 0037296803

Structure Descriptors

InChI

1S/C8H23N5.ClH/c9-1-3-11-5-7-13-8-6-12-4-2-10;/h11-13H,1-10H2;1H

InChIKey

GACQNVJDWUAPFY-UHFFFAOYSA-N

Smiles

C(CNCCNCCNCCN)N.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal > 4gm/kg (4000mg/kg)   Toxicology and Applied Pharmacology. Vol. 28, Pg. 57, 1974.
mouse LD50 oral > 1gm/kg (1000mg/kg)   Toxicology and Applied Pharmacology. Vol. 28, Pg. 57, 1974.
rat LD50 intraperitoneal 53mg/kg (53mg/kg)   Toxicology and Applied Pharmacology. Vol. 28, Pg. 57, 1974.
rat LD50 oral > 1gm/kg (1000mg/kg)   Toxicology and Applied Pharmacology. Vol. 28, Pg. 57, 1974.