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Substance Name: Dimetacrine tartrate
RN: 3759-07-7
UNII: DVH164X0IF
InChIKey: IIYKUJVECNNTEY-LREBCSMRSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C20-H26-N2.C4-H6-O6

Molecular Weight

  • 444.525
 
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Names and Synonyms

Results Name

  • Dimetacrine tartrate

Name of Substance

  • Dimetacrine bitartrate

Synonyms

  • 10(9H)-Acridinepropanamine, N,N,9,9-tetramethyl-, (R-(R*,R*))-2,3-dihydroxybutanedioate (1:1)
  • 10-(3-(Dimethylamino)propyl)-9,9-dimethylacridan tartrate (1:1)
  • 9,9-Dimethyl-10-dimethylaminopropylacridan hydrogen tartrate
  • Dimetacrin (R,R)-hydrogentartrat
  • Dimetacrin hydrogentartrate
  • Dimetacrine bitartrate
  • Dimetacrine tartrate
  • EINECS 223-166-8
  • Istonil
  • Istonyl
  • Linostil
  • Miroistonil
  • MO 709
  • SD 709
  • UNII-DVH164X0IF

Systematic Names

  • 10(9H)-Acridinepropanamine, N,N,9,9-tetramethyl-, (2R,3R)-2,3-dihydroxybutanedioate (1:1)
  • Acridan, 10-(3-(dimethylamino)propyl)-9,9-dimethyl-, tartrate (1:1) (8CI)
  • Dimethyl(3-(9,9-dimethyl-10(9H)-acridinio)propyl)ammonium (R-(R*,R*))-tartrate

Registry Numbers

CAS Registry Number

  • 3759-07-7

FDA UNII

  • DVH164X0IF

Other Registry Number

  • 33299-81-9

System Generated Number

  • 0003759077

Molecular Formulas

Molecular Formula

  • C20-H26-N2.C4-H6-O6

Molecular Formula Fragments

  • C20-H26-N2
  • C4-H6-O6
  • COMPONENT

Structure Descriptors

InChI

1S/C20H26N2.C4H6O6/c1-20(2)16-10-5-7-12-18(16)22(15-9-14-21(3)4)19-13-8-6-11-17(19)20;5-1(3(7)8)2(6)4(9)10/h5-8,10-13H,9,14-15H2,1-4H3;1-2,5-6H,(H,7,8)(H,9,10)/t;1-,2-/m.1/s1

InChIKey

IIYKUJVECNNTEY-LREBCSMRSA-N

Smiles

c12c(C(c3ccccc3N2CCCN(C)C)(C)C)cccc1.C([C@@H]([C@H](C(=O)O)O)O)(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 intravenous 40mg/kg (40mg/kg) BEHAVIORAL: STIFFNESS

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: ATAXIA
Wiener Klinische Wochenschrift. Vol. 78, Pg. 21, 1966.
cat LD50 oral 150mg/kg (150mg/kg) BEHAVIORAL: STIFFNESS

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: ATAXIA
Wiener Klinische Wochenschrift. Vol. 78, Pg. 21, 1966.
mouse LD50 intraperitoneal 175mg/kg (175mg/kg) BEHAVIORAL: AGGRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Wiener Klinische Wochenschrift. Vol. 78, Pg. 21, 1966.
mouse LD50 intravenous 40900ug/kg (40.9mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 855, 1970.
mouse LD50 oral 755mg/kg (755mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR
Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1278, 1981.
mouse LD50 subcutaneous 798mg/kg (798mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA
Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 855, 1970.
rat LD50 intraperitoneal 203mg/kg (203mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA
Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 855, 1970.
rat LD50 intravenous 38mg/kg (38mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA
Wiener Klinische Wochenschrift. Vol. 78, Pg. 21, 1966.
rat LD50 oral 1671mg/kg (1671mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1098, 1974.
rat LD50 subcutaneous 1214mg/kg (1214mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 855, 1970.