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Substance Name: Maraviroc [INN:BAN:JAN]
RN: 376348-65-1
UNII: MD6P741W8A
InChIKey: GSNHKUDZZFZSJB-QYOOZWMWSA-N

Note

  • AIDSinfo: Maraviroc, also known as Selzentry, is a chemokine receptor antagonist that acts as an entry inhibitor. It is designed to prevent HIV infection of CD4 cells by blocking chemokine receptor 5 (CCR5), a coreceptor necessary for HIV entry, from binding to HIV.

    DailyMed: SELZENTRY is a CCR5 co-receptor antagonist indicated for combination antiretroviral treatment of adults infected with only CCR5-tropic HIV-1, who have evidence of viral replication and HIV-1 strains resistant to multiple antiretroviral agents. Tropism testing is required for the appropriate use of SELZENTRY.

Molecular Formula

  • C29-H41-F2-N5-O

Molecular Weight

  • 513.6729
 

Classification Codes

  • Anti-HIV Agents
  • Anti-Infective Agents
  • Anti-Retroviral Agents
  • Antiviral Agents
  • CCR5 Receptor Antagonists

Names and Synonyms

Name of Substance

  • Maraviroc
  • Maraviroc [INN:BAN:JAN]

Synonyms

  • Celsentri
  • HSDB 8021
  • Isopropyl, 4,4-difluoro-N-((1S)-3-{(1R,3s,5S)-3-(3-methyl-5-(propan-2-yl)-4H-1,2,4-triazol-4-yl)-8-azabicyclo(3.2.1)octan-8-yl}-1-phenylpropyl)cyclohexanecarboxamide
  • Maraviroc
  • MVC
  • Selzentry
  • UK 427857
  • UK-427,857
  • UNII-MD6P741W8A

Systematic Name

  • Cyclohexanecarboxamide, 4,4-difluoro-N-((1S)-3-((3-exo)-3-(3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl)-8-azabicyclo(3.2.1)oct-8-yl)-1-phenylpropyl)-

Registry Numbers

CAS Registry Number

  • 376348-65-1

FDA UNII

  • MD6P741W8A

Other Registry Number

  • 674782-29-7

System Generated Number

  • 0376348651

Structure Descriptors

InChI

1S/C29H41F2N5O/c1-19(2)27-34-33-20(3)36(27)25-17-23-9-10-24(18-25)35(23)16-13-26(21-7-5-4-6-8-21)32-28(37)22-11-14-29(30,31)15-12-22/h4-8,19,22-26H,9-18H2,1-3H3,(H,32,37)/t23-,24+,25-,26-/m0/s1

InChIKey

GSNHKUDZZFZSJB-QYOOZWMWSA-N

Smiles

Cc1nnc(n1[C@@H]2C[C@H]3CC[C@@H](C2)N3CC[C@@H](c4ccccc4)NC(=O)C5CCC(CC5)(F)F)C(C)C