Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Terguride [INN]
RN: 37686-84-3
UNII: 21OJT43Q88
InChIKey: JOAHPSVPXZTVEP-YXJHDRRASA-N

Note

  • Pronounced antifertility agent in rats; lactation suppressor in other species; serotonin antagonist.

Molecular Formula

  • C20-H28-N4-O

Molecular Weight

  • 340.4682
 

Classification Codes

  • Dopamine Agents
  • Dopamine Agonists
  • Drug / Therapeutic Agent
  • Human Data
  • Neurotransmitter Agents
  • Reproductive Effect
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Dironyl
  • Terguride
  • Terguride [INN]

Synonyms

  • (+)-(5R,8S,10R)-Terguride
  • (+)-Terguride
  • (5R,8S,10R)-Terguride
  • 1-((5R,8S,10R)-6-Methyl-8-ergolinyl)-3,3-diethylurea
  • 6-Methyl-8alpha-(diethylcarbamoylamino)ergoline
  • 9,10-alpha-Dihydrolisuride
  • BRN 0766582
  • Dironyl
  • EINECS 253-624-2
  • N,N-Diethyl-N'-(D-6-methyl-10alpha-isoergolin-8-yl)urea
  • Tergurida
  • Tergurida [Spanish]
  • Terguride
  • Terguridum
  • Terguridum [Latin]
  • trans-Dihydrolisuride
  • UNII-21OJT43Q88
  • ZK 31224

Systematic Names

  • 1,1-Diethyl-3-(6-methylergolin-8alpha-yl)urea
  • Terguride
  • Urea, N,N-diethyl-N'-((8-alpha)-6-methylergolin-8-yl)-

Registry Numbers

CAS Registry Number

  • 37686-84-3

FDA UNII

  • 21OJT43Q88

Other Registry Number

  • 85649-11-2

Related Registry Number

  • 37686-85-4 (maleate[1:1])

System Generated Number

  • 0037686843

Structure Descriptors

InChI

1S/C20H28N4O/c1-4-24(5-2)20(25)22-14-10-16-15-7-6-8-17-19(15)13(11-21-17)9-18(16)23(3)12-14/h6-8,11,14,16,18,21H,4-5,9-10,12H2,1-3H3,(H,22,25)/t14-,16+,18+/m0/s1

InChIKey

JOAHPSVPXZTVEP-YXJHDRRASA-N

Smiles

CCN(CC)C(=O)N[C@H]1C[C@H]2[C@@H](Cc3c[nH]c4cccc2c34)N(C)C1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
monkey LD50 oral > 500mg/kg (500mg/kg)   Drugs in Japan Vol. -, Pg. 832, 1995.
mouse LD50 intraperitoneal 272mg/kg (272mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

KIDNEY, URETER, AND BLADDER: INCONTINENCE

KIDNEY, URETER, AND BLADDER: HEMATURIA
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 21, Pg. 329, 1993.
mouse LD50 intravenous 75mg/kg (75mg/kg)   Collection of Czechoslovak Chemical Communications. Vol. 52, Pg. 2983, 1987.
mouse LD50 oral 160mg/kg (160mg/kg) KIDNEY, URETER, AND BLADDER: INCONTINENCE

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 21, Pg. 329, 1993.
mouse LD50 subcutaneous > 2gm/kg (2000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 21, Pg. 329, 1993.
rat LD50 intraperitoneal 2gm/kg (2000mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION

KIDNEY, URETER, AND BLADDER: INCONTINENCE
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 21, Pg. 329, 1993.
rat LD50 oral 100mg/kg (100mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 21, Pg. 329, 1993.
rat LD50 subcutaneous > 2gm/kg (2000mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION

KIDNEY, URETER, AND BLADDER: INCONTINENCE
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 21, Pg. 329, 1993.