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Substance Name: Sufosfamide [INN]
RN: 37753-10-9
UNII: 2208Y59985
InChIKey: ZSZKJARKHWCBJK-UHFFFAOYSA-N

Note

  • Stronger immunosuppressive activity than cyclophosphamide.

Classification Codes

  • Drug / Therapeutic Agent
  • Mutation Data

Molecular Formula

  • C8-H18-Cl-N2-O5-P-S

Molecular Weight

  • 320.732
 
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Names and Synonyms

Name of Substance

  • Sufosfamide
  • Sufosfamide [INN]

Synonyms

  • 2-((3-(2-Chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-yl)amino)ethanol methanesulfonate (ester) P-oxide
  • 3-(2-Chloroethyl)-2-(2-mesyloxyethylamino)tetrahydro-2H-1,3,2-oxazaphosphorin-2-oxide
  • ASTA 5122
  • Sufosfamide
  • Sufosfamido
  • Sufosfamido [INN-Spanish]
  • Sufosfamidum
  • Sufosfamidum [INN-Latin]
  • UNII-2208Y59985

Systematic Names

  • 2-((3-(2-Chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-yl)amino)ethanol methanesulfonate (ester) P-oxide
  • Ethanol, 2-((3-(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-yl)amino)-, methanesulfonate (ester), P-oxide

Registry Numbers

CAS Registry Number

  • 37753-10-9

FDA UNII

  • 2208Y59985

System Generated Number

  • 0037753109

Structure Descriptors

InChI

1S/C8H18ClN2O5PS/c1-18(13,14)16-8-4-10-17(12)11(6-3-9)5-2-7-15-17/h2-8H2,1H3,(H,10,12)

InChIKey

ZSZKJARKHWCBJK-UHFFFAOYSA-N

Smiles

C1CCO[P@@](=O)(NCCOS(C)(=O)=O)[N@@]1CCCl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 136mg/kg (136mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1149, 1974.
mouse LD50 intravenous 91mg/kg (91mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1149, 1974.
rat LD50 intraperitoneal 120mg/kg (120mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1149, 1974.
rat LD50 intravenous 102mg/kg (102mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1149, 1974.