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Substance Name: Todralazine hydrochloride [JAN]
RN: 3778-76-5
UNII: C59540FEXP
InChIKey: OMCOKCNIYWULQH-UHFFFAOYSA-N

Note

  • An antihypertensive agent with both central and peripheral action; it has some central nervous system depressant effects.

Molecular Formula

  • C11-H12-N4-O2.Cl-H

Molecular Weight

  • 268.7027
 

Classification Codes

  • Antihypertensive Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Mutation Data
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Todralazine
  • Todralazine hydrochloride
  • Todralazine hydrochloride [JAN]

MeSH Heading

  • Todralazine

Synonyms

  • 621-BT hydrochloride
  • Apirachol
  • Binazin
  • Binazine
  • CCRIS 5090
  • Ecarazine
  • Ecarazine hydrochloride
  • N1-Ethoxy carbonyl-N2-hydrazinophthalazine hydrochloride
  • Todralazine hydrochloride
  • UNII-C59540FEXP

Systematic Names

  • Carbazic acid, 3-(1-phthalazinyl)-, ethyl ester, monohydrochloride
  • Ecarazine hydrochloride
  • Hydrazinecarboxylic acid, 2-(1-phthalazinyl)-, ethyl ester, monohydrochloride (9CI)

Registry Numbers

CAS Registry Number

  • 3778-76-5

FDA UNII

  • C59540FEXP

System Generated Number

  • 0003778765

Molecular Formulas

Molecular Formula

  • C11-H12-N4-O2.Cl-H

Molecular Formula Fragments

  • C11-H12-N4-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C11H12N4O2.ClH/c1-2-17-11(16)15-14-10-9-6-4-3-5-8(9)7-12-13-10;/h3-7H,2H2,1H3,(H,13,14)(H,15,16);1H

InChIKey

OMCOKCNIYWULQH-UHFFFAOYSA-N

Smiles

CCOC(=O)NNc1c2ccccc2cnn1.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 501mg/kg (501mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BLOOD: HEMORRHAGE
Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 29, 1969.
mouse LD50 intravenous 300mg/kg (300mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 97, 1969.
mouse LD50 oral 516mg/kg (516mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 97, 1969.
mouse LD50 subcutaneous 319mg/kg (319mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 97, 1969.
rabbit LD50 intraperitoneal 450mg/kg (450mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BLOOD: HEMORRHAGE

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 29, 1969.
rabbit LD50 intravenous 417mg/kg (417mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BLOOD: HEMORRHAGE

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 29, 1969.
rabbit LD50 oral 399mg/kg (399mg/kg) BLOOD: HEMORRHAGE

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 29, 1969.
rat LD50 intraperitoneal 200mg/kg (200mg/kg) BLOOD: HEMORRHAGE

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 29, 1969.
rat LD50 intravenous 240mg/kg (240mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BLOOD: HEMORRHAGE
Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 29, 1969.
rat LD50 oral 598mg/kg (598mg/kg) BLOOD: HEMORRHAGE

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 29, 1969.
rat LD50 subcutaneous 466mg/kg (466mg/kg) BLOOD: HEMORRHAGE

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 29, 1969.