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Substance Name: Betamethasone [USAN:USP:INN:BAN:JAN]
RN: 378-44-9
UNII: 9842X06Q6M
InChIKey: UREBDLICKHMUKA-DVTGEIKXSA-N
Note
- A glucocorticoid given orally, parenterally, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. Its lack of mineralocorticoid properties makes betamethasone particularly suitable for treating cerebral edema and congenital adrenal hyperplasia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p724).
Molecular Formula
- C22-H29-F-O5
Molecular Weight
- 392.4641
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Adrenal Cortex Hormones
- Anti-Asthmatic Agents
- Anti-Inflammatory Agents
- Drug / Therapeutic Agent
- Glucocorticoid
- Glucocorticoids
- Hormones
- Hormones, Hormone Substitutes, and Hormone Antagonists
- Reproductive Effect
- Respiratory System Agents
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Names and Synonyms
Name of Substance
- Betamethasone
- Betamethasone [USAN:USP:INN:BAN:JAN]
MeSH Heading
- Betamethasone
Synonyms
- 16-beta-Methyl-1,4-pregnadiene-9-alpha-fluoro-11-beta,17-alpha,21-triol-3,20-dione
- 4-08-00-03501 (Beilstein Handbook Reference)
- 9-alpha-Fluoro-16-beta-methyl-1,4-pregnadiene-11-beta,17-alpha,21-triol-3,20-dione
- 9-alpha-Fluoro-16-beta-methylprednisolone
- 9-Fluoro-11-beta,17,21-trihydroxy-16-beta-methylpregna-1,4-diene-3,20-dione
- 9-Fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione
- 9-Fluoro-16beta-methylprednisolone
- 9alpha-Fluoro-16beta-methylprednisolone
- Bebate
- Becort
- Bedifos
- beta-Methasone
- beta-Methasone alcohol
- Betacorlan
- Betacortril
- Betadexamethasone
- Betafluorene
- Betamamallet
- Betametasona
- Betametasona [INN-Spanish]
- Betametasone
- Betametasone [DCIT]
- Betamethasone
- Betamethasone alcohol
- Betamethasone cream
- Betamethasone, topical
- Betamethasonum
- Betamethasonum [INN-Latin]
- Betamethazone
- Betapredol
- Betasolon
- Betnelan
- Betsolan
- BRN 3176546
- Celestene
- Celestone
- Celestone Syrup and Tablets
- Cidoten
- Corticosterone, 1-dehydro-9-fluoro-17-hydroxy-16beta-methyl-
- Desacort-beta
- EC 206-825-4
- EINECS 206-825-4
- Flubenisolone
- Hormezon
- HSDB 3015
- Methazon
- NSC 39470
- NSC-39470
- Prednisolone, 9-fluoro-16beta-methyl-
- Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11beta,16beta)-
- Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17,21-trihydroxy-16beta-methyl-
- Rinderon
- Rinderon A
- Sch 4831
- UNII-9842X06Q6M
- Valisone
- Visubeta
Systematic Names
- Betamethasone
- Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11beta,16beta)-
- Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17,21-trihydroxy-16beta-methyl-
Registry Numbers
CAS Registry Number
- 378-44-9
FDA UNII
- 9842X06Q6M
System Generated Number
- 0000378449
Structure Descriptors
InChI
InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1InChIKey
UREBDLICKHMUKA-DVTGEIKXSA-NSmiles
C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | oral | > 4500mg/kg (4500mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 2117, 1979. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 232 | deg C | EXP | |
log P (octanol-water) | 1.94 | (none) | EXP | |
Water Solubility | 66.5 | mg/L | 25 | EXP |
Vapor Pressure | 8.86E-14 | mm Hg | 25 | EST |
Henry's Law Constant | 7.15E-08 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 6.95E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.