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Substance Name: Viomycin sulfate [USP]
RN: 37883-00-4
UNII: LKO141R05V
InChIKey: AQONYROJHRNYQQ-QMAPKBLTSA-N

Note

  • A strongly basic peptide, antibiotic complex from several strains of Streptomyces. It is allergenic and toxic to kidneys and the labyrinth. Viomycin is used in tuberculosis as several different salts and in combination with other agents.

Molecular Formula

  • C25-H43-N13-O10.x-H2-O4-S

Molecular Weight

  • 783.7735
 

Classification Code

  • Drug / Therapeutic Agent
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Names and Synonyms

Name of Substance

  • Viomycin sulfate [USP]

Synonyms

  • Celicomycin-sulfate
  • Florimycin sulfate
  • Solfato di viomicina
  • Solfato di viomicina [Italian]
  • UNII-LKO141R05V
  • Viocin
  • Viocin sulfate
  • Viomycin sulfate
  • Viomycin-sulfat
  • Viomycin-sulfat [German]

Systematic Name

  • Viomycin, sulfate (salt)

Registry Numbers

CAS Registry Number

  • 37883-00-4

FDA UNII

  • LKO141R05V

Other Registry Numbers

  • 1404-97-3
  • 19272-75-4
  • 34458-90-7

System Generated Number

  • 0037883004

Molecular Formulas

Molecular Formula

  • C25-H43-N13-O10.x-H2-O4-S

Molecular Formula Fragments

  • C25-H43-N13-O10
  • COMPONENT
  • H2-O4-S

Structure Descriptors

InChI

1S/C25H43N13O10.H2O4S/c26-3-1-2-10(27)4-16(41)32-12-6-30-23(47)18(11-5-17(42)37-24(28)36-11)38-20(44)13(7-31-25(29)48)33-21(45)14(8-39)35-22(46)15(9-40)34-19(12)43;1-5(2,3)4/h7,10-12,14-15,17-18,39-40,42H,1-6,8-9,26-27H2,(H,30,47)(H,32,41)(H,33,45)(H,34,43)(H,35,46)(H,38,44)(H3,28,36,37)(H3,29,31,48);(H2,1,2,3,4)/b13-7-;/t10-,11+,12-,14-,15-,17-,18-;/m0./s1

InChIKey

AQONYROJHRNYQQ-QMAPKBLTSA-N

Smiles

NCCC[C@H](N)CC(=O)N[C@H]1CNC(=O)[C@@H](NC(=O)\C(=C\NC(=O)N)\NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC1=O)[C@H]2C[C@H](O)NC(=N2)N.OS(=O)(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD oral > 7500mg(base) (7500mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
Arzneimittel-Forschung. Drug Research. Vol. 6, Pg. 61, 1956.
mouse LD50 intramuscular 840mg/kg (840mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 817, 1974.
mouse LD50 intraperitoneal 973mg/kg (973mg/kg)   Antibiotiki. Vol. 8, Pg. 910, 1963.
mouse LD50 intravenous 112mg/kg (112mg/kg)   Farmaco, Edizione Scientifica. Vol. 12, Pg. 899, 1957.
mouse LD50 subcutaneous 1184mg/kg (1184mg/kg)   Antibiotiki. Vol. 8, Pg. 910, 1963.
rat LD50 intramuscular 1300mg/kg (1300mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 817, 1974.
rat LD50 intravenous 340mg/kg (340mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 817, 1974.