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Substance Name: Pertuzumab [USAN:INN:BAN]
RN: 380610-27-5
UNII: K16AIQ8CTM

Notes

  • A humanized HER-2 monoclonal antibody; prevents ERBB2 receptor protein from binding (dimerizing) to other receptors in the HER family.
  • A humanized HER-2 monoclonal antibody; prevents ERBB2 receptor protein from binding (dimerizing) to other receptors in the HER family.

    NCI: A humanized recombinant monoclonal antibody directed against the extracellular dimerization domain of the HER-2 tyrosine kinase receptor. Binding of the antibody to the dimerization domain of the HER-2 tyrosine kinase receptor protein directly inhibits the ability of the HER-2 tyrosine kinase receptor protein (the most common pairing partner) to dimerize with other HER tyrosine kinase receptor proteins; inhibiting receptor protein dimerization prevents the activation of HER signaling pathways, resulting in tumor cell apoptosis. NCI Thesaurus)
 

Classification Codes

  • Anti-Neoplastic
  • Antineoplastic Agents
  • Antineoplastic Agents, Immunological
  • HER-2-Targeting Antibody
  • Monoclonal Antibody

Names and Synonyms

Name of Substance

  • Pertuzumab
  • Pertuzumab [USAN:INN:BAN]

Synonyms

  • 2C4
  • HSDB 8141
  • Omnitarg
  • Omnitarg, 2C4
  • Perjeta
  • Pertuzumab
  • rhuMAb 2C4
  • UNII-K16AIQ8CTM

Systematic Name

  • Immunoglobulin G1, anti-(human v (receptor)) (human-mouse monoclonal 2C4 heavy chain), disulfide with human-mouse monoclonal 2C4 kappa-chain, dimer

Registry Numbers

CAS Registry Number

  • 380610-27-5

FDA UNII

  • K16AIQ8CTM

System Generated Number

  • 0380610275